Tumor M2-pyruvate kinase, a new metabolic marker for pancreatic cancer

Digestive Diseases and Sciences
Maurizio VentrucciLucio Gullo

Abstract

An isoenzyme of pyruvate kinase (Tu M2-PK) is overexpressed by tumor cells and can be measured in blood by a specific immunoenzymatic assay. Our objective was to investigate the diagnostic value of Tu M2-PK in comparison with that of CA 19-9 in pancreatic cancer. We studied 265 subjects: 60 with histologically confirmed pancreatic cancer, 43 with benign pancreatic diseases (acute and chronic pancreatitis), 5 with benign cystic neoplasms of the pancreas, 9 with neuroendocrine tumors, 77 with other abdominal malignancies, 47 with benign digestive diseases, and 24 healthy controls. Levels of plasma Tu M2-PK and serum CA 19-9 were determined by commercially available specific immunoassays. The diagnostic sensitivity and specificity of Tu M2-PK for pancreatic cancer were 85 and 41%, respectively, while those of CA 19-9 were 75 and 81%. The combination of the two tests significantly increased sensitivity (97%) but lowered specificity (38%). In discriminating between pancreatic cancer and acute or chronic pancreatitis, Tu M2-PK turned out to be less accurate than CA 19-9. In patients without pancreatic tumor, cholestasis appeared not to affect the values of Tu M2-PK, while CA 19-9 was found to be significantly higher. Tu M2-PK was als...Continue Reading

Citations

Feb 24, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xiao-Li DuMing-Rong Wang
Feb 13, 2008·Langenbeck's Archives of Surgery·Lucia C FryPeter Malfertheiner
Apr 2, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yogesh KumarBrian R Davidson
May 24, 2005·Seminars in Cancer Biology·Sybille MazurekErich Eigenbrodt
Jul 31, 2008·Pancreas·Herwig Cerwenka
Oct 13, 2009·Pancreas·Maiken Thyregod JoergensenOve B Schaffalitzky de Muckadell
Sep 6, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K KossJ A Z Jankowski
Jul 3, 2007·Annals of Surgical Oncology·Harsha R HathurusingheAjith K Siriwardena
Dec 27, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Peter StaibTimo Schinköthe
May 3, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhe Huang, Fang Liu
Jan 5, 2011·Journal of Cancer Research and Clinical Oncology·S BüngerJ K Habermann
Sep 13, 2008·Expert Review of Molecular Diagnostics·Philip D Hardt, Nils Ewald
Jul 5, 2008·Expert Review of Molecular Diagnostics·Cristiana Pistol Tanase
Sep 1, 2007·Expert Opinion on Medical Diagnostics·Vitor Faca, Samir Hanash
Sep 1, 2009·Expert Opinion on Medical Diagnostics·Cristiana Pistol TanaseSimona Olimpia Dima
Jul 8, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M VentrucciG Uomo
Feb 5, 2008·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Juergen ErvensBodo Hoffmeister
Nov 14, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K S Goonetilleke, A K Siriwardena
Jan 1, 2010·Cancers·Felix RückertRobert Grützmann
Sep 14, 2007·Scandinavian Journal of Gastroenterology·Elzbieta CzubJarosław Walkowiak
Jun 28, 2019·PloS One·Weiya LiuEugene K Lee
Mar 21, 2009·European Journal of Gastroenterology & Hepatology·Matt W JohnsonJohn R Nicholls
Sep 13, 2008·European Journal of Gastroenterology & Hepatology·Yogesh KumarBrian R Davidson
Feb 16, 2007·European Journal of Gastroenterology & Hepatology·Yogesh KumarBrian R Davidson
Nov 17, 2006·World Journal of Gastroenterology : WJG·Carolin TonusMarkus Sellinger
Mar 30, 2016·World Journal of Gastroenterology : WJG·Anthony K C ChanAjith K Siriwardena
Apr 22, 2015·World Journal of Gastroenterology : WJG·Si-Biao SuHai-Xing Jiang
Apr 2, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Takashi KobayashiMasaru Yoshida
Jul 31, 2021·World Journal of Gastroenterology : WJG·Robert S O'Neill, Alina Stoita

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