Tumor macrophages as a target for Capsaicin mediated immunotherapy

Cancer Letters
Amiya K Ghosh, S Basu

Abstract

Tumor microenvironment contributes to a large extent for failure of immunological destruction of antigenic tumors. Most solid tumors adapt to the microenvironment and escape the host immune system. The dramatic and systemic effectiveness of neuro-immune ligand Capsaicin (CP) in regression of established solid tumors led us to investigate its immunomodulatory role in tumor microenvironment. In this report we demonstrate that CP induced tumor cell apoptosis leads to increased sensitization of the surrounding stroma manifested by enhanced antigen presentation by stromal macrophages and its destruction by tumor specific T-cells. Further, CP injection alters the tumor microenvironment with regards to tumor-infiltrating Treg cells as well as the cytokine milieu at the tumor site. Our data collectively demonstrates that injection of CP sets in motion, a cascade of several independent innate and adaptive immunological events initiated at the tumor environment.

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Citations

Jan 27, 2016·Autoimmunity Reviews·Yaxiong DengYehuda Shoenfeld
Sep 16, 2014·Nutrition·Maria Saveria Gilardini MontaniFrancesca Velotti
Jul 18, 2020·Journal of Leukocyte Biology·Li-Juan DengJia-Xu Chen
Feb 28, 2017·Food Science and Biotechnology·Seok-Cheol ChoBu Young Choi
Jul 25, 2019·European Journal of Medicinal Chemistry·Shijie ZhaoYumeng Wei
Feb 17, 2021·Critical Reviews in Food Science and Nutrition·Fengzhang WangXiaojun Liao
Apr 23, 2021·Advanced Drug Delivery Reviews·Juan GuanChangyou Zhan

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