PMID: 7034921Feb 15, 1982Paper

Tumor markers in inclusion cysts of the ovary

Cancer
A BlausteinJ Wells

Abstract

The immunoperoxidase method was used to determine whether carcinoembryonic antigen, beta subunit of HCG placental lactogen, pregnancy-associated alpha-2 glycoprotein, and pregnancy-specific beta-1 glycoprotein could be found in inclusion cysts of the ovary. These tumor markers are found in the serum of patients with common epithelial carcinomas of the ovary and inclusion cysts are considered to be the origin of these tumors. Placental lactogen was found in 56 of 118 inclusion cysts, beta subunit of HCG in four of 141 cysts, alpha-2 glycoprotein in five of 141, and beta-1 glycoprotein in two of 118. it was concluded that primitive cells in inclusion cysts elaborate the same tumor markers found in serous cystadenoma and cystadenocarcinoma of the ovary. This observation, although not proving origin of tumor from the inclusion cyst, demonstrates a significant characteristic shared in common by all three.

References

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Citations

Jan 1, 1995·Journal of Cellular Biochemistry. Supplement·R E Scully
Jan 1, 1995·Journal of Cellular Biochemistry. Supplement·V V Baker
Jan 1, 1989·International Urology and Nephrology·H KosmehlF Kiss
Dec 6, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T C HamiltonB C Vanderhyden
Nov 26, 2008·Journal of Ovarian Research·Nicholas B Berry, Sharmila A Bapat
Jul 1, 1988·Gynecologic Oncology·G J Fleuren, M Nap
Apr 28, 2007·Endocrine Reviews·Jung-Hye ChoiPeter C K Leung
Feb 1, 1995·Biological Reviews of the Cambridge Philosophical Society·I Zusman
Apr 11, 2001·Endocrine Reviews·N AuerspergP C Leung
Nov 7, 2007·The Journal of Veterinary Medical Science·Yuko AkiharaHiroyuki Taniyama
Oct 7, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sally M HunterIan G Campbell

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