PMID: 9167746Jun 1, 1997Paper

Tumor markers in the diagnosis of malignant serous effusions

American Journal of Clinical Oncology
S CascinuG Catalano

Abstract

To assess the possibility of increasing the detection rates of cytological examination in malignant effusions by the selection of specific tumor markers for a given type of tumor, we measured CEA, CA 19.9, CA 15.3, MCA, PSA, and AFP in malignant effusions from 89 patients with the following primary malignancies: colon, stomach, breast, liver, prostate, lung, and kidney. Cytological examination was positive in only 35 of 89 patients (40%), while the tumor markers were positive in 72 of 89 cases (80%). However, apart from small cell lung and kidney cancers, where the lack of a specific tumor marker resulted in no advantage, in the other types of tumors, the specific marker for each tumor identified correctly malignant effusions in 72 of 74 cases (97%). In fact, CEA was positive in 11 of 11 effusions induced by colorectal cancer; CA 19.9 in 28 of 30 gastric cancer effusions, while MCA and CA 15.3 were positive in breast cancer effusions (16/22 and 20/22). Finally, elevated AFP and PSA indicated hepatocellular and prostate cancer, respectively. In conclusion, in cancer patients with elevated effusion levels of specific tumor markers, the effusions could be considered of a malignant nature even without cytologically demonstrable tum...Continue Reading

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Citations

Jun 5, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Victoria VillenaJuana Estenoz-Alfaro
Oct 13, 2005·Southern Medical Journal·Pablo García de Paso MoraRodríguez Juan José Vázquez
Apr 22, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Huan-Zhong ShiHai-Bo Yang
May 11, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·I KanellosD Betsis
Dec 1, 1997·Medizinische Klinik·M BergH Schieffer
May 29, 2004·The American Journal of the Medical Sciences·Vasu AppalaneniMichael A Baumann
Mar 5, 2004·International Journal of Clinical Practice·Hasan UstünAhmet Yilmaz
Jan 11, 2008·Respiration; International Review of Thoracic Diseases·Marios E Froudarakis
Feb 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Xin-Feng WangYun-Shan Wang
Jul 23, 2003·The American Journal of Gastroenterology·Jean Louis FrossardMonique Fabre
Oct 18, 2020·Gut·Guruprasad P AithalSumita Verma
Mar 31, 2021·Scientific Reports·D KuettingF Kütting

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