Tumor mechanosensing and its therapeutic potential

Journal of Cellular Biochemistry
Antonios N GargalionisAthanasios G Papavassiliou

Abstract

Cancer mechanics have lately emerged as a distinct tumor feature that promotes tumor development, invasion, and metastasis. Tumor mechanosensing involves a mechanical interplay between cancer cells, extracellular matrix, and cells of the surrounding stroma. Mechanoreceptors sense alterations of the extracellular mechanical cues and activate signaling molecules, which mediate oncogenic transcription in favor of cancer initiation, survival, growth, and metastasis. Furthermore, alterations of the matrix rigidity and activation of mechano-induced transcriptional regulators has been strongly associated with resistance to anti-cancer agents. In this context, new mechanosensitive molecules arise as potential therapeutic targets. Therefore, tumor mechanosignaling represents a promising field that can potentially offer new combination regimens to overcome drug resistance, but also suggest novel targeting strategies.

References

Jul 6, 2010·The International Journal of Biochemistry & Cell Biology·Georgia DalagiorgouAthanasios G Papavassiliou
Jun 19, 2013·Trends in Molecular Medicine·Shalom MadarVarda Rotter
Aug 16, 2014·International Journal of Cancer. Journal International Du Cancer·Antonios N GargalionisAthanasios G Papavassiliou
Nov 10, 2014·EMBO Reports·Michael W PickupValerie M Weaver
Jul 23, 2015·Kidney International·Albert C M Ong, Peter C Harris
Dec 25, 2015·Trends in Molecular Medicine·Antonios N GargalionisAthanasios G Papavassiliou
Jun 6, 2016·Current Opinion in Pharmacology·Francesca ZanconatoStefano Piccolo
Jun 15, 2016·Annual Review of Cell and Developmental Biology·Laralynne PrzybylaValerie M Weaver
Jun 15, 2016·Cancer Cell·Francesca ZanconatoStefano Piccolo
Jul 28, 2016·Journal of Cellular Biochemistry·Christos AdamopoulosAthanasios G Papavassiliou
Nov 18, 2016·International Journal of Molecular Sciences·Stefanie LöffekIris Helfrich
Feb 9, 2017·Cancer Cell International·Liviu FellerJohan Lemmer
Mar 28, 2017·Current Opinion in Chemical Engineering·LiKang ChinPaul A Janmey
Jul 28, 2017·Science Translational Medicine·Linan LiuWeian Zhao
Sep 22, 2017·The Journal of Cell Biology·Youmna AttiehDanijela Matic Vignjevic
Oct 17, 2017·Nature Communications·Alexandros GlentisDanijela Matic Vignjevic
Nov 15, 2017·Journal of Cellular and Molecular Medicine·Antonios N GargalionisAthanasios G Papavassiliou
Dec 5, 2017·The Journal of Clinical Investigation·Zhousheng XiaoL Darryl Quarles
Dec 16, 2017·International Journal of Cancer. Journal International Du Cancer·Antonios N GargalionisAthanasios G Papavassiliou

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Citations

Nov 22, 2018·Journal of Cellular Biochemistry·Antonios N GargalionisAthanasios G Papavassiliou
May 6, 2019·International Journal of Molecular Sciences·Antonios N GargalionisAthanasios G Papavassiliou
Dec 21, 2019·Journal of Cellular Physiology·Anderson M GomesWillian F Zambuzzi
Jun 1, 2020·Cancer Metastasis Reviews·Vibha Singh, Christophe Lamaze
Jan 2, 2019·International Journal of Molecular Sciences·Antonios N GargalionisAthanasios G Papavassiliou
Jun 21, 2020·Cancer Letters·Antonios N GargalionisPenelope Korkolopoulou
Jun 8, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Parinaz AbdollahiyanAhad Mokhtarzadeh
Oct 29, 2021·Journal of Biomedical Nanotechnology·Qingxuan WangChenchen Zhou

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