Tumor metabolism and associated serum metabolites define prognostic subtypes of Asian hepatocellular carcinoma.

Scientific Reports
Yotsawat PomyenTIGER-LC Consortium

Abstract

Treatment effectiveness in hepatocellular carcinoma (HCC) depends on early detection and precision-medicine-based patient stratification for targeted therapies. However, the lack of robust biomarkers, particularly a non-invasive diagnostic tool, precludes significant improvement of clinical outcomes for HCC patients. Serum metabolites are one of the best non-invasive means for determining patient prognosis, as they are stable end-products of biochemical processes in human body. In this study, we aimed to identify prognostic serum metabolites in HCC. To determine serum metabolites that were relevant and representative of the tissue status, we performed a two-step correlation analysis to first determine associations between metabolic genes and tissue metabolites, and second, between tissue metabolites and serum metabolites among 49 HCC patients, which were then validated in 408 additional Asian HCC patients with mixed etiologies. We found that certain metabolic genes, tissue metabolites and serum metabolites can independently stratify HCC patients into prognostic subgroups, which are consistent across these different data types and our previous findings. The metabolic subtypes are associated with β-oxidation process in fatty acid...Continue Reading

References

Jan 2, 1993·International Journal of Cancer. Journal International Du Cancer·M C HollsteinR Montesano
Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Sep 7, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ju-Seog LeeSnorri S Thorgeirsson
Apr 28, 2006·Nature Genetics·Michael ReichJill P Mesirov
Jul 24, 2007·Bioinformatics·Aravind SubramanianJill P Mesirov
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·T Andrew ClaytonJeremy K Nicholson
Apr 30, 2010·Bioinformatics·Matthew D Wilkerson, D Neil Hayes
Jul 16, 2013·Biochimica Et Biophysica Acta·Sara ViolanteSander M Houten
Nov 28, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Roongruedee ChaiteerakijLewis R Roberts
Dec 18, 2013·Bioinformatics·Andreas KrämerStuart Tugendreich
Jan 3, 2014·International Journal of Cancer. Journal International Du Cancer·Yue LiuYifeng Chai
May 9, 2014·Journal of the American Society of Nephrology : JASN·Raymond VanholderGriet Glorieux
Jul 12, 2014·Journal of the American Society of Nephrology : JASN·Chiao-Yin SunChin-Chan Lee
Jul 26, 2015·Database : the Journal of Biological Databases and Curation·Natapol PornputtapongJens Nielsen
May 10, 2016·Nature Reviews. Disease Primers·Josep M LlovetGregory Gores
Jul 12, 2016·Biomarkers in Cancer·Ranjit Chauhan, Nivedita Lahiri
Oct 26, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Charline LeroiGonzague Jourdain
Sep 21, 2016·The Journal of Clinical Endocrinology and Metabolism·G XuPeter Plomgaard
Oct 18, 2016·Journal of Clinical and Experimental Hepatology·Mohamed I F ShariffSimon D Taylor-Robinson
May 5, 2017·Biomarkers in Cancer·Jiatao LouShuai Jiang
Jun 18, 2017·Cell·UNKNOWN Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu, UNKNOWN Cancer Genome Atlas Research Network
Jun 24, 2017·Journal of Hepatology·Jian-Gao FanVincent Wai-Sun Wong
Jun 27, 2017·Cancer Cell·Jittiporn ChaisaingmongkolUNKNOWN TIGER-LC Consortium
Jul 6, 2017·Nature Reviews. Gastroenterology & Hepatology·Le-Xing Yu, Robert F Schwabe
Apr 10, 2018·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Aug 1, 2018·Nature Reviews. Clinical Oncology·Josep M LlovetRichard S Finn

❮ Previous
Next ❯

Software Mentioned

GenePattern
GSEA
KEGG API
SubMap
Ingenuity Pathway Analysis ( IPA )
R package pathview
R
ConsensusClusterPlus 16
KEGGREST

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.