Tumor microenvironment - Unknown niche with powerful therapeutic potential

Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology
Tomasz KolendaKatarzyna M Lamperska

Abstract

Head and neck squamous cell carcinomas (HNSCC) are in a group of cancers that are the most resistant to treatment. The survival rate of HNSCC patients has been still very low since last 20 years. The existence of relationship between oncogenic and surrounding cells is probably the reason for a poor response to treatment. Fibroblasts are an important element of tumor stroma which increases tumor cells ability to proliferate. Another highly resistance, tumorigenic and metastatic cell population in tumor microenvironment are cancer initiating cells (CICs). The population of cancer initiating cells can be found regardless of differentiation status of cancer and they seem to be crucial for HNSCC development. In this review, we describe the current state of knowledge about HNSCC biological and physiological tumor microenvironment.

References

Feb 18, 1999·Current Opinion in Chemical Biology·E C JonathanW G McKenna
Aug 10, 2004·International Journal of Cancer. Journal International Du Cancer·Qunzhou ZhangAnh D Le
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Dec 28, 2005·Seminars in Radiation Oncology·Desirée HaoGeorge P Browman
Oct 27, 2006·International Journal of Cancer. Journal International Du Cancer·Eri SasabeTokio Osaki
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·M E PrinceL E Ailles
Jul 28, 2007·Journal of Cellular Physiology·Alexandra Cretu, Peter C Brooks
Feb 12, 2008·Oral Oncology·Crispian Scully, Jose V Bagan
Feb 26, 2008·Nature Cell Biology·Muh-Hwa YangKou-Juey Wu
Jun 12, 2008·Seminars in Oncology·Kevin T PalkaChristine H Chung
Jul 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shih-Hwa ChiouJeng-Fan Lo
Nov 7, 2008·Nature Reviews. Cancer·Jessica A BertoutM Celeste Simon
Dec 26, 2008·Haematologica·Muzlifah A HaniffaFrancesco Dazzi
May 20, 2009·Biochemical and Biophysical Research Communications·Yu-Chih ChenWen-Liang Lo
Jun 2, 2009·Neoplasia : an International Journal for Oncology Research·Kathleen G NeivaJacques E Nör
Nov 4, 2009·Nature Reviews. Genetics·Urban LendahlLorenz Poellinger
Jun 12, 2010·Cytogenetic and Genome Research·B J Henson, S M Gollin
Sep 22, 2010·Nature Immunology·Subhra K Biswas, Alberto Mantovani
Nov 26, 2010·Cancer Research·Sudha KrishnamurthyJacques E Nör
Feb 22, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Cheng-Chi ChangMark Y P Kuo
Feb 24, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Lo-Lin TsaiMing-Yung Chou
Apr 23, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jens Overgaard
Oct 15, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kasper ToustrupUNKNOWN Danish Head and Neck Cancer Group (DAHANCA)
Oct 22, 2011·Oral Oncology·Marcia S CamposJacques E Nör
Nov 15, 2011·Oral Oncology·Shailesh M GondivkarSwati Balsaraf
Nov 29, 2011·Cell·Peter Friedl, Stephanie Alexander
Jul 12, 2012·International Journal of Cancer. Journal International Du Cancer·Wei LiuZeng-Tong Zhou
Mar 19, 2013·Brazilian Journal of Otorhinolaryngology·Priscilla Suassuna Carneiro LúcioCassiano Francisco Weege Nonaka
Jul 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amanda EustaceCatharine M L West

❮ Previous
Next ❯

Citations

Oct 28, 2019·Scientific Reports·Maria HarmatiKrisztina Buzas
Feb 14, 2019·Journal of Biomedical Science·Tomasz KolendaKatarzyna Lamperska
Apr 24, 2019·Cells·Tomasz KolendaJacek Mackiewicz
Nov 8, 2020·International Journal of Molecular Sciences·Xinyu QuKatie Meehan
May 25, 2021·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Roberto BruschiniMohssen Ansarin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Travis D ReevesM Boyd Gillespie
World Journal of Otorhinolaryngology - Head and Neck Surgery
Kyle P McMullenKris R Jatana
© 2022 Meta ULC. All rights reserved