Tumor microenvironment after biodegradable BCNU wafer implantation: special consideration of immune system

Journal of Neuro-oncology
Ichiyo ShibaharaToshihiro Kumabe

Abstract

Biomaterials to treat cancers hold therapeutic potential; however, their translation to bedside treatment requires further study. The carmustine (1,3-bis (2-chloroethyl)-1-nitrosourea; BCNU) wafer, a biodegradable polymer, currently is the only drug that is able to be placed at the surgical site to treat malignant tumors. However, how this wafer affects the surrounding tumor microenvironment is not well understood to date. We retrospectively reviewed all patients with glioblastoma treated with and without BCNU wafers who underwent repeat resection at tumor recurrence. We investigated radiological imaging; the interval between the two surgeries; and immunohistochemistry of CD3, CD4, CD8, CD20, CD68, FOXP3, and PD1. We implanted BCNU wafers in 41 newly diagnosed glioblastoma patients after approval of the wafer in Japan. Of them, 14 underwent surgery at recurrence and tissue was obtained from around the wafers. The interval between the first and second surgeries ranged from 63 to 421 days. The wafer could be observed on magnetic resonance imaging at up to 226 days, whereas intraoperatively the biodegraded material of the wafer could be found at up to 421 days after the initial surgery. Immunohistochemical analysis demonstrated th...Continue Reading

References

Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Dec 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eiichi SatoKunle Odunsi
Dec 16, 2006·Journal of Neuro-oncology·H Christopher LawsonHenry Brem
Dec 29, 2007·Seminars in Immunology·James M AndersonDavid T Chang
Jul 12, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Giuseppe PerroneFrancesco Graziano
Dec 3, 2008·Journal of Neurosurgery·Matthew J McGirtAlfredo Quiñones-Hinojosa
Mar 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrea MerloAndrea Balsari
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sahar M A MahmoudAndrew R Green
Jun 29, 2011·British Journal of Neurosurgery·Young-Hee KimJe-Jung Lee
Aug 24, 2012·Science Translational Medicine·Melody A SwartzJeffrey A Hubbell
Oct 12, 2012·Cellular and Molecular Life Sciences : CMLS·Erik H J G AarntzenI Jolanda M de Vries
Oct 23, 2012·Journal of Neurosurgery·Kaisorn L ChaichanaAlfredo Quiñones-Hinojosa
Jul 19, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Caleb RutledgeDaniel J Brat
Apr 18, 2014·Neurologia Medico-chirurgica·Tomokazu AokiUNKNOWN NPC-08 study group
Oct 31, 2014·Neuro-oncology·Anna Sophie BerghoffWolfgang Wick
Dec 17, 2014·Nature Biotechnology·Sirkka B StephanMatthias T Stephan
Jan 30, 2015·Journal of Neuro-oncology·Sajeel A ChowdharyHerbert B Newton
Jul 18, 2015·Neuro-oncology·Johan PalludUNKNOWN Club de Neuro-Oncologie of the Société Française de Neurochirurgie
Dec 24, 2015·Nature Reviews. Cancer·Luo Gu, David J Mooney
Feb 13, 2016·Oncotarget·Joshua M GammonChristopher M Jewell
Feb 21, 2016·Current Opinion in Biotechnology·Sandeep T Koshy, David J Mooney
Jun 11, 2016·Journal of Neurosurgery·Kiyotaka SaitoHideo Takeshima
Oct 8, 2016·BMC Bioinformatics·John Christian Givhan Spainhour, Peng Qiu
Nov 5, 2016·Journal of Biomedical Materials Research. Part a·R Klopfleisch, F Jung
Apr 15, 2017·World Neurosurgery·Chikezie I EseonuAlfredo Quinones-Hinojosa

❮ Previous
Next ❯

Citations

Dec 17, 2020·Pharmaceutics·Jessica I GriffithWilliam F Elmquist
Mar 30, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ichiyo ShibaharaToshihiro Kumabe
Jan 19, 2022·Journal of Internal Medicine·Sneha RathiWilliam F Elmquist

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.