PMID: 18711258Aug 20, 2008Paper

Tumor necrosis factor--alpha and transforming growth factor--beta1 polymorphisms in bronchial asthma

Indian Journal of Medical Sciences
Ajay KumarPrabodh K Sehajpal

Abstract

Bronchial asthma is a complex genetic disorder regulated by the release of cytokines and inflammatory mediators. Tumor necrosis factor alpha (TNF-alpha) and transforming growth factor beta (TGF-beta1) cytokines play pivotal roles in the inflammatory response of the airways. Differential production of these two cytokines is associated with allelic variations in the transcriptional regulatory region of these genes. The objective of the present study was to investigate G-308A TNF-alpha and C-509T TGF- beta1 polymorphisms for their association with Bronchial Asthma. DNA isolated from 123 asthmatics and 100 normal healthy controls were screened for these polymorphisms using the amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) methods, developed in our laboratory. Significant allelic association was observed between G-308A TNF-alpha polymorphism and asthma (P = 0.031) while no association was observed with C-509T TGF- beta1 polymorphism (P = 0.207). Further sub-grouping based on either allergic response or family history failed to reveal any statistical significance among the groups or with controls. The interaction between these polymorphisms revealed statistically significant association between the hig...Continue Reading

Citations

Jun 5, 2019·Genetic Testing and Molecular Biomarkers·Sang Wook KangJu Yeon Ban
Nov 26, 2010·PloS One·Sven MichelMichael Kabesch
Apr 23, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yonggang ZhangHong Fan
Oct 9, 2013·Molecular and Cellular Biochemistry·Roli SaxenaJyotdeep Kaur
Nov 11, 2020·Clinical Reviews in Allergy & Immunology·Ambika SharmaHarish Changotra

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