Tumor necrosis factor-alpha -308A/G polymorphism is associated with age at onset of Alzheimer's disease

Mechanisms of Ageing and Development
D LioC Caruso

Abstract

Pro-inflammatory cytokines and acute-phase proteins play an important role in Alzheimer's disease (AD) neurodegeneration, and common polymorphisms of genes controlling their production have been shown to be associated with AD. Tumor necrosis factor (TNF)-alpha is an inflammatory cytokine involved in the local immune response occurring in the central nervous system of AD patients. Genetic variation could contribute to the risk of developing AD or influence the age at the onset of the disease. We genotyped 222 patients (152 women, 70 men; age range 60-87) and 240 non-demented age-matched healthy controls for TNF-alpha -308 G/A single nucleotide polymorphism (SNP). No significant differences were observed in genotyped frequencies between patients and controls, whereas carriers of -308A showed a significantly lower mean age at onset than non-carriers of this allele. This difference was more evident taking into account ApolipoproteinE (ApoE) status since the lowest age at onset was observed in patients carrying the -308ATNF+/APOE4+ genotypes. In conclusion, our data support previous suggestions that, at least in Caucasians, the TNF gene is a disease modifier gene in patients in which AD is rising, bringing to light the importance of...Continue Reading

References

Nov 16, 2001·Archives of Neurology·P L McGeer, E G McGeer
Jan 5, 2002·Neurobiology of Aging·P L McGeer, E G McGeer
Sep 17, 2002·Neuromolecular Medicine·Ekaterina Rogaeva
Jan 25, 2003·Experimental Gerontology·Georg WickBeatrix Grubeck-Loebenstein
Apr 26, 2003·Mechanisms of Ageing and Development·Federico Licastro, Martina Chiappelli
Jul 11, 2003·The New England Journal of Medicine·Calogero CarusoFederico Licastro
Apr 20, 2004·Neuroreport·Daniela UbertiMaurizio Memo
May 5, 2004·Archives of General Psychiatry·Ara S KhachaturianUNKNOWN Cache County Study Investigators
May 17, 2006·Aging Clinical and Experimental Research·Domenico LioCalogero Caruso

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Citations

Oct 8, 2008·Neuroscience Bulletin·Ying WanSheng-Di Chen
Jun 19, 2013·Journal of Neurotrauma·Ryan J WatersJames A R Nicoll
Aug 23, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M C Déniz-NaranjoF Sánchez-García
Jan 11, 2008·Journal of Neuroinflammation·Edward L Tobinick, Hyman Gross
Nov 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Minkyu L KimVirginia M-Y Lee
Dec 19, 2007·Pharmacogenomics·Sonya VastoCalogero Caruso
Jul 8, 2014·Drug Discovery Today·Xin ChengRena Li
Jun 15, 2012·Cellular and Molecular Life Sciences : CMLS·Angeles Almeida
Jun 4, 2010·Expert Review of Neurotherapeutics·Edward Tobinick
Mar 15, 2016·The Lancet Oncology·Jeffrey S WefelMichael E Scheurer
Oct 27, 2009·Archives of Gerontology and Geriatrics·A P CerriG Annoni
Jul 10, 2008·Ageing Research Reviews·Robertina GiacconiEugenio Mocchegiani
Oct 5, 2007·Neurobiology of Aging·K S KrabbeH Bruunsgaard
Nov 23, 2006·Mechanisms of Ageing and Development·Giuseppina CandoreCalogero Caruso
Dec 29, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Yih-Ru WuChiung-Mei Chen
Aug 21, 2008·Geriatrics & Gerontology International·Tomio AraiNoriko Tanaka
Feb 25, 2009·Annals of the New York Academy of Sciences·Ricardo B MaccioniRodrigo O Kuljis
Mar 1, 2008·Clinical and Experimental Immunology·S TaudorfH Bruunsgaard
Apr 18, 2008·Journal of Neuroscience Research·Jigisha R Patel, Gregory J Brewer
Jul 21, 2009·International Journal of Geriatric Psychiatry·Anna Paola CerriGiorgio Annoni
Dec 11, 2007·Archives of Medical Research·Leonel E RojoRicardo B Maccioni
Apr 7, 2007·Neurosurgery·Marco FontanellaLorenzo Pinessi
May 19, 2017·Molecular Pharmaceutics·Rudy ChangRachita K Sumbria
Jan 13, 2015·British Dental Journal·T L CerajewskaN X West
Jan 31, 2007·Annals of the New York Academy of Sciences·Letizia ScolaSergio Palmeri
Jan 31, 2007·Annals of the New York Academy of Sciences·Giuseppina CandoreCalogero Caruso
Jul 18, 2008·Fetal and Pediatric Pathology·Nasrin PerskvistUlla Palm
Dec 21, 2011·Journal of Immunoassay & Immunochemistry·Marisa PalmeriDomenico Lio

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