PMID: 8590306Nov 1, 1995Paper

Tumor necrosis factor alpha and interleukin-1 alpha stimulate late shedding of p75 TNF receptors but not p55 TNF receptors from human monocytes

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
D A Joyce, J H Steer

Abstract

Soluble receptors for TNF (sTNF-R) are present at elevated concentrations in the synovial fluid of patients with rheumatoid arthritis. They are presumably released by cells of the synovial membrane, including the monocyte-derived synovial macrophages. Cytokines from the synovium, including IL-1 and TNF-alpha, may stimulate release. We therefore examined the release of sTNF-R from monocytes exposed to IL-1 and TNF-alpha. Elutriator-purified human blood monocytes spontaneously released both the p75 and the p55 sTNF-R (1011 +/- 199 and 177 +/- 20 pg/10(6) cells, respectively, mean +/- SEM) during 48 h of in vitro culture. TNF-alpha and IL-1 alpha induced time- and concentration-dependent increases in the release of sTNF-R75 from monocytes, but neither had a measurable effect on the release of sTNF-R55. The release of sTNF-R75 was inhibited by cycloheximide. Neither lymphocytes nor polymorphonuclear leukocytes (PMN) released measurable sTNF-R spontaneously or in response to stimulation with IL-1 alpha, but TNF-alpha stimulated the release of small amounts of sTNF-R75 by PMN. The timing, cycloheximide sensitivity, and selectivity of stimulated release of TNF-R75 by monocytes are consistent with previous observations on other cell ty...Continue Reading

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Citations

Oct 22, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·C P. CoyneBrad W. Fenwick
Apr 1, 1998·Trends in Cardiovascular Medicine·R C Leboeuf, S A Schreyer
Jul 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·D A JoyceA Kloda
Jul 30, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Patrick J ShawRobert A Roth
Sep 1, 1996·The Journal of Pharmacy and Pharmacology·H M LengP I Folb
Feb 24, 2001·Journal of the American Geriatrics Society·P E MarikUNKNOWN NORASEPT II Study Investigators. North American Sepsis Trial II
May 12, 2000·Osteoarthritis and Cartilage·C I WestacottC J Elson
Apr 18, 1998·Chemistry & Biology·L L Kiessling, E J Gordon
Nov 2, 2014·Arthritis Research & Therapy·Julie K LaustsenBent Deleuran
Jul 27, 2017·Terapevticheskiĭ arkhiv·N A MukhinL V Kozlovskaya
Jan 19, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E VoogG Salles

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