PMID: 9182689Jun 16, 1997Paper

Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitis

The Journal of Experimental Medicine
K FreiA Fontana

Abstract

Immunization of mice with myelin components results in experimental autoimmune encephalomyelitis (EAE), which is mediated by myelin-specific CD4(+) T cells and anti-myelin antibodies. Tumor necrosis factor alpha (TNF-alpha) and lymphotoxin alpha (LT-alpha) are thought to be involved in the events leading to inflammatory demyelination in the central nervous system. To ascertain this hypothesis 129 x C57BL/6 mice with an inactivation of the tnf and lta genes (129 x C57BL/6(-/-)) and SJL/J mice derived from backcrosses of the above mentioned mutant mice (SJL-/-) were immunized with mouse spinal cord homogenate (MSCH) or proteolipid protein. Both 129 x C57BL/6(-/-) mice and SJL-/- mice developed EAE. In SJL-/- mice immunized with MSCH, a very severe form of EAE with weight loss, paralysis of all four limbs, and lethal outcome was observed. The histologic hallmark was an intense perivascular and parenchymal infiltration with predominantly CD4(+) T cells and some CD8(+) T cells associated with demyelination in both brain and spinal cord. These results indicate that TNF-alpha and LT-alpha are not essential for the development of EAE.

References

Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J E MerrillF M Hofman
Nov 1, 1991·Annals of Neurology·K SelmajA H Cross
Nov 1, 1991·Journal of Neuroimmunology·Y Kuroda, Y Shimamoto
Mar 1, 1991·The Journal of Clinical Investigation·K SelmajC F Brosnan
Apr 1, 1988·Annals of Neurology·K W Selmaj, C S Raine
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·L ProbertG Kollias
Jul 1, 1996·European Journal of Immunology·M Krakowski, T Owens
Dec 1, 1996·The Journal of Experimental Medicine·S D WolfC A Janeway

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Citations

Mar 4, 1999·European Journal of Immunology·H P EugsterA Fontana
Jul 31, 1998·Clinical Immunology and Immunopathology·B M Segal, E M Shevach
Jan 8, 2004·Journal of Autoimmunity·Aiden C J MarshallFrank Alderuccio
Feb 21, 2004·Journal of Neuroimmunology·Stefan JungKlaus Toyka
Nov 24, 1999·Journal of the Neurological Sciences·C S ConstantinescuA M Rostami
Jul 20, 2000·Journal of Neuroimmunology·J A EdwardsP J Talbot
Jun 22, 1999·Journal of Neuroimmunology·A UnciniD Gambi
Jul 30, 1999·Journal of Neuroimmunology·J Antel
Apr 27, 2000·Immunology Today·H DrakesmithP Beverley
Jul 23, 2003·Neuroscience Research·Shin HisaharaMasayuki Miura
May 26, 1999·Progress in Neurobiology·G Stoll, S Jander
Mar 11, 1998·Current Opinion in Immunology·A O'GarraK Gijbels
Oct 1, 1998·Cytokine & Growth Factor Reviews·J J Lafaille
Jun 12, 2002·Cell Death and Differentiation·B M SimonM Leist
Apr 29, 1998·Immunology and Cell Biology·S R Ruuls, J D Sedgwick
Jun 2, 1998·Kidney International·C J KellyD P Gold
Mar 28, 1998·The Journal of Experimental Medicine·B M SegalE M Shevach
Jan 4, 2001·The Journal of Experimental Medicine·S HisaharaM Miura
Jul 11, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Y OkudaT Yanagihara
Dec 1, 1999·Annals of the Rheumatic Diseases·C LockL Steinman

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