PMID: 9431855Feb 12, 1998Paper

Tumor necrosis factor-alpha-angiotensin interactions and regulation of blood pressure

Journal of Hypertension
N R FerreriJ C McGiff

Abstract

To compare the levels of tumor necrosis factor-alpha (TNF) produced by medullary thick ascending limb tubules (MTAL) obtained from normotensive and angiotensin II (Ang II)-dependent hypertensive rats and determine whether TNF participates in a mechanism that opposes elevation of blood pressure by Ang II. We have previously demonstrated that in-vitro administration of Ang II increases production of TNF and prostaglandin E2 (PGE2) by the MTAL. We hypothesize that production of TNF and PGE2 by the MTAL is elevated in in-vivo models of Ang II-dependent hypertension and acts to modulate the pressor effects of Ang II. Thus, inhibition of TNF should disclose whether this cytokine acts to modulate Ang II-induced hypertension. MTAL tubules obtained from normotensive and Ang II-dependent hypertensive rats were isolated by enzymatic digestion and sieving. Tubules were cultured in the absence of exogenous Ang II. TNF and PGE2 levels were measured by enzyme-linked immunosorbent assay. Anti-TNF antiserum was administered intravenously to normotensive and Ang II-dependent hypertensive rats and their mean arterial pressures were measured. Production of TNF and PGE2 was significantly greater in MTAL tubules isolated from Ang II hypertensive rat...Continue Reading

References

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Citations

Nov 1, 2003·Thrombosis Research·Nicholas R FerreriMairead A Carroll
Apr 18, 2001·Prostaglandins & Other Lipid Mediators·B Askari, N R Ferreri
Jan 3, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G HolcbergL Myatt
Dec 20, 1999·General Pharmacology·D G JohnsR C Webb
Nov 2, 2002·Kidney International. Supplement·Marta Ruiz-OrtegaJesus Egido
Mar 31, 2012·American Journal of Physiology. Renal Physiology·Alexander CastilloDewan S A Majid
Oct 17, 2008·American Journal of Physiology. Renal Physiology·Mohd ShahidDewan S A Majid
Jan 20, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Koichi YamaguchiKazuaki Shimamoto
Feb 19, 2014·Current Hypertension Reports·Keisa W MathisMichael J Ryan
Feb 24, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·H ShimizuM Mori
Dec 3, 2014·Medical Hypotheses·Jessica R Gomolak, Sean P Didion
Dec 3, 2003·American Journal of Physiology. Cell Physiology·Ivan A ArenasSandra T Davidge
Dec 11, 2013·Hypertension·Lesley A GrahamMartin W McBride
Nov 30, 2006·Journal of the American Society of Nephrology : JASN·Jose HerreraBernardo Rodriguez-Iturbe
Dec 29, 2005·American Journal of Physiology. Renal Physiology·Huda Ismail AbdullahNicholas R Ferreri
Mar 22, 2013·American Journal of Physiology. Renal Physiology·Vanesa D Ramseyer, Jeffrey L Garvin
Aug 27, 2010·American Journal of Physiology. Renal Physiology·Chun Cheng Andy ChenNicholas R Ferreri
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Vladimir TodorovArmin Kurtz
Nov 23, 2007·American Journal of Physiology. Renal Physiology·Huda Ismail AbdullahNicholas R Ferreri
Sep 14, 1999·The American Journal of Physiology·J C McGiff, J Quilley
Feb 8, 2013·American Journal of Physiology. Renal Physiology·Purnima SinghDewan S A Majid
Sep 6, 2000·Clinical and Experimental Hypertension : CHE· Sheu WHHY T Chen
Nov 4, 2000·Journal of Biomedical Science·D G JohnsR C Webb
Oct 30, 2020·Human & Experimental Toxicology·Yasmine A AbdelhamidOsama A Badary
Feb 11, 2021·Arquivos brasileiros de cardiologia·İsmet DurmuşTuncay Kırış
Dec 30, 2009·The Journal of Experimental Biology·W W DowdD Kültz
Mar 30, 2010·The Journal of Sexual Medicine·Fernando S CarneiroRita C Tostes

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