Tumor necrosis factor-alpha attenuates thyroid hormone-induced apoptosis in vascular endothelial cell line XLgoo established from Xenopus tadpole tails

Endocrinology
Shuuji MawaribuchiMichihiko Ito

Abstract

Amphibian metamorphosis induced by T(3) involves programmed cell death and the differentiation of various types of cells in degenerated and reconstructed tissues. However, the signaling pathway that directs the T(3)-dependent cell-fate determinations remains unclear. TNF-alpha is a pleiotropic cytokine that affects diverse cellular responses. Engagement of TNF-alpha with its receptor (TNFR1) causes intracellular apoptotic and/or survival signaling. To investigate TNF signaling functions during anuran metamorphosis, we first identified Xenopus laevis orthologs of TNF (xTNF)-alpha and its receptor. We found that xTNF-alpha activated nuclear factor-kappaB in X. laevis A6 cells through the Fas-associated death domain and receptor-interacting protein 1. Interestingly, xTNF-alpha mRNA in blood cells showed prominent expression at prometamorphosis during metamorphosis. Next, to elucidate the apoptotic and/or survival signaling induced by xTNF-alpha in an in vitro model of metamorphosis, we established a vascular endothelial cell line, XLgoo, from X. laevis tadpole tail. XLgoo cells formed actin stress fibers and elongated in response to xTNF-alpha. T(3) induced apoptosis in these cells, but the addition of xTNF-alpha blocked the T(3)-...Continue Reading

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Citations

Mar 20, 2010·Apoptosis : an International Journal on Programmed Cell Death·Atsuko Ishizuya-OkaYun-Bo Shi
Jul 2, 2014·Developmental and Comparative Immunology·Jason SifkarovskiJacques Robert
Apr 30, 2011·Developmental and Comparative Immunology·Gregory D Wiens, Gavin W Glenney
Oct 15, 2013·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Eberhard R Horn, Martin Gabriel
Mar 21, 2015·Journal of Molecular Endocrinology·Kei TamuraMichihiko Ito
Sep 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria ForlenzaGeert F Wiegertjes
Apr 24, 2021·Stem Cell Research·Rina Otsuka-YamaguchiMari Dezawa

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis