Tumor necrosis factor-alpha contributes to below-level neuropathic pain after spinal cord injury

Annals of Neurology
Xiang-min PengMarina Mata

Abstract

Our objective was to elucidate the mechanisms responsible for below-level pain after partial spinal cord injury (SCI). We used lateral hemisection to model central neuropathic pain and herpes simplex viral (HSV) vector-mediated transfer of the cleaved soluble receptor for tumor necrosis factor-alpha (TNF-alpha) to evaluate the role of TNF-alpha in the pathogenesis of below-level pain. We found activation of microglia and increased expression of TNF-alpha below the level of the lesion in the lumbar spinal cord after T13 lateral hemisection that correlated with emergence of mechanical allodynia in the hind limbs of rats. Lumbar TNF-alpha had an apparent molecular weight of 27 kDa, consistent with the full-length transmembrane form of the protein (mTNF-alpha). Expression of the p55 TNF soluble receptor (sTNFRs) by HSV-mediated gene transfer resulted in reduced pain behavior and a decreased number of ED1-positive cells, as well as decreased phosphorylation of the p38 MAP kinase (p-p38) and diminished expression of mTNF-alpha in the dorsal horn. These results suggest that expression of mTNF-alpha after injury is related to development of pain, and that reverse signaling through mTNF-alpha by sTNFR at that level reduces cellular mark...Continue Reading

References

Oct 1, 1994·Experimental Neurology·C J GarrisonS M Carlton
Sep 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J A DeLeoA Malhotra
Aug 1, 1997·Journal of Neurotrauma·M D Christensen, C E Hulsebosch
Jun 6, 1998·Experimental Neurology·C SommerA George
Nov 20, 1998·Journal of Neuroscience Methods·K A MöllerO G Berge
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G EissnerE Holler
Jan 3, 2001·The Journal of Clinical Investigation·P P Tak, G S Firestein
Aug 22, 2001·Pain·L R WatkinsS F Maier
Jan 5, 2002·Progress in Medicinal Chemistry·J L AdamsJ C Lee
Oct 16, 2002·Glia·Uwe-Karsten Hanisch
May 8, 2003·The Journal of Pharmacology and Experimental Therapeutics·Vasudeva RaghavendraJoyce A DeLeo
Sep 3, 2003·Nature Reviews. Drug Discovery·Sanjay KumarJohn C Lee
Jan 30, 2004·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N B Finnerup, T S Jensen
May 18, 2004·Neurochemistry International·Julie Wieseler-FrankLinda R Watkins
Oct 30, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Georg H WaetzigStefan Schreiber
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jamie CampbellBrian M J Foxwell
Nov 30, 2004·Trends in Molecular Medicine·Michael S Beattie
Apr 22, 2005·Neuroscience Letters·Camilla I SvenssonLinda S Sorkin
Sep 10, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Chao FangHong-Zhuan Chen

❮ Previous
Next ❯

Citations

May 12, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Pablo AndradeGovert Hoogland
Oct 9, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Joseph C Glorioso, David J Fink
Nov 12, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shuanglin HaoDavid J Fink
Nov 11, 2009·The Journal of Biological Chemistry·Xiangmin PengMarina Mata
Aug 12, 2010·Journal of Neurotrauma·Olivera NesicPonnada A Narayana
Jul 24, 2010·Journal of Neurotrauma·Laura M SundbergPonnada A Narayana
Apr 12, 2007·International Anesthesiology Clinics·Shuanglin HaoDavid J Fink
Jan 23, 2008·The Clinical Journal of Pain·Erik Dahl, Steven P Cohen
Nov 24, 2011·Pain Research and Treatment·Yu HuangWanhong Liu
Nov 24, 2011·Pain Research and Treatment·Chalonda R HandyNicholas Boulis
Dec 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Manuel D GalvanAileen J Anderson
Oct 13, 2012·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Indu Pal Kaur, Gaurav Sharma
Mar 26, 2011·Journal of Biomedicine & Biotechnology·Aya NakaeTakashi Mashimo
Jul 8, 2015·Expert Review of Hematology·Yongfeng ChenYong Liang
Jun 2, 2011·Expert Opinion on Biological Therapy·Nikolai G Rainov, Volkmar Heidecke
May 13, 2015·Molecular Pain·Jean-Marc G GuedonShuanglin Hao
Oct 13, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Darren WolfeDavid J Fink
May 13, 2008·Neuroscience and Biobehavioral Reviews·Hong Cao, Yu-Qiu Zhang
Jan 23, 2015·Frontiers in Molecular Neuroscience·Ryan S TonkinGila Moalem-Taylor
Nov 2, 2011·Respiratory Physiology & Neurobiology·James A Windelborn, Gordon S Mitchell
Dec 23, 2016·Neuroscience Letters·Jenny HaefeliAdam R Ferguson
May 2, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Fred C KoR Sean Morrison
Sep 28, 2017·Neural Plasticity·Young S GwakJoong Woo Leem
Oct 14, 2008·European Journal of Pain : EJP·Fabien MarchandStephen B McMahon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.