PMID: 11344046May 10, 2001Paper

Tumor necrosis factor-alpha cooperates with receptor activator of nuclear factor kappaB ligand in generation of osteoclasts in stromal cell-depleted rat bone marrow cell culture

Bone
M KomineO Kohashi

Abstract

A member of the tumor necrosis factor (TNF) family, receptor activator of nuclear factor kappaB ligand (RANKL; also known as ODF, OPGL, and TRANCE), plays critical roles in osteoclast differentiation and activation in the presence of macrophage colony-stimulating factor (M-CSF). Recently, TNF-alpha has also been shown to induce the formation of multinucleated osteoclast-like cells (MNCs) in the presence of M-CSF from mouse macrophages. We demonstrated that mononuclear preosteoclast-like cells (POCs) were formed in the presence of conditioned medium of osteoblastic cells in a rat bone marrow culture depleted of stromal cells. Using this culture system, in this study we examined whether TNF-alpha affects differentiation into POCs from hematopoietic progenitor cells. Human TNF-alpha (hTNF-alpha) markedly stimulated the formation of POCs. Moreover, a concentration as low as 0.005 ng/mL of hTNF-alpha increased the level of mRNA for calcitonin receptor (CTR) and cathepsin-K of POCs. The POCs induced by hTNF-alpha formed MNCs, which showed dentine-resorbing activity after coculture with primary osteoblasts. Stimulation was observed after 24 h of treatment with hTNF-alpha only on day 1 or day 2 of the culture. After 24 h of hTNF-alpha ...Continue Reading

References

May 1, 1992·Immunology Today·L A Tartaglia, D V Goeddel
Feb 1, 1992·Endocrine Reviews·T SudaT J Martin
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M LewisD V Goeddel
Nov 1, 1988·Endocrinology·N TakahashiT Suda
Apr 1, 1986·Journal of Clinical Periodontology·J D Sterrett
Dec 1, 1982·The Journal of Experimental Medicine·E H BurgerR van Furth
Jan 5, 1995·Biochemical and Biophysical Research Communications·T InaokaT Kokubo
May 3, 1996·Cell·M FeldmannR N Maini
May 1, 1996·Current Opinion in Rheumatology
Jun 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R B KimbleR Pacifici
Aug 18, 1997·The Journal of Experimental Medicine·T KamedaM Kumegawa
Nov 14, 1997·Nature Medicine·V IotsovaR Bravo
Feb 7, 1998·Genes & Development·G FranzosoU Siebenlist
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·H YasudaT Suda
Jan 23, 1999·The American Journal of Pathology·K D MerkelS L Teitelbaum
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·H HsuW J Boyle
Sep 29, 1999·Genes & Development·W C DougallJ Schuh
Dec 22, 1999·FEBS Letters·D E MyersG C Nicholson
Feb 15, 2000·The Journal of Biological Chemistry·Y AzumaA Kudo
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·J LiW J Boyle
Feb 29, 2000·Arthritis and Rheumatism·E M GravalleseS R Goldring

❮ Previous
Next ❯

Citations

Jan 20, 2011·Rheumatology International·Simona Angela BarnabaVincenzo Denaro
Apr 20, 2006·Journal of Bone and Mineral Metabolism·Chie WadaToshihiko Nagata
Oct 31, 2007·Journal of Bone and Mineral Metabolism·Kenji OgawaTakao Hotokebuchi
Jan 30, 2004·Cytokine & Growth Factor Reviews·Steeve Kwan TatYannick Fortun
Jun 20, 2003·Experimental Gerontology·Bruce R Troen
Nov 17, 2010·Cell Research·Deborah Veis Novack
Jun 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sae OchiHiroshi Takayanagi
Jun 18, 2004·Current Opinion in Rheumatology·Nicole C Walsh, Ellen M Gravallese
Apr 7, 2007·Current Opinion in Rheumatology·Gust VerbruggenDirk Elewaut
Jul 20, 2012·Current Opinion in Rheumatology·Vivian K KawaiMarie R Griffin
Oct 9, 2014·Journal of Immunology Research·Seung Min JungJi Hyeon Ju
Feb 1, 2008·Expert Opinion on Drug Discovery·Gabriel Mbalaviele, Joseph B Monahan
Feb 3, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Qi XiongPeifu Tang
Jan 30, 2016·Stem Cells International·Wessam E Sharaf-EldinNagwa El-Badri
Sep 16, 2015·The Tohoku Journal of Experimental Medicine·Xingwang NingWei Wang
May 8, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jesse S SiffledeenRichard N Fedorak
Jul 13, 2006·Annals of the New York Academy of Sciences·Bruce R Troen
Jul 13, 2006·Annals of the New York Academy of Sciences·Jameel Iqbal
Nov 30, 2005·Immunological Reviews·Nicole C WalshEllen M Gravallese
Jul 19, 2013·Clinical & Developmental Immunology·Addolorata CorradoFrancesco Paolo Cantatore
Nov 25, 2004·Cytokine & Growth Factor Reviews·Sandrine TheoleyreDominique Heymann
Sep 10, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S Perez-AmodioV Everts
May 11, 2002·Leukemia & Lymphoma·Richard E Clark, William D Fraser
Jun 15, 2013·Biochemical and Biophysical Research Communications·Sahar Karieb, Simon W Fox
Jan 14, 2012·PloS One·Isidoro González-ÁlvaroRosario García-Vicuña
Feb 10, 2007·Expert Review of Anticancer Therapy·M Baud'huinM Padrines
Apr 3, 2003·Clinical Orthopaedics and Related Research·Jörgen AstrandPer Aspenberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.