Tumor necrosis factor-alpha downregulates adrenomedullin receptors in human coronary artery smooth muscle cells

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Yasuko NagoshiTanenao Eto

Abstract

We examined the effects of tumor necrosis factor (TNF)-alpha on the expression and functionality of adrenomedullin (AM) receptors in cultured human coronary artery smooth muscle cells. Analysis of real-time quantitative polymerase chain reactions showed that these cells abundantly express two AM receptors comprised of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) or RAMP2. TNF-alpha induced time- and dose-dependent decreases in the expression of CRLR and RAMP1/2 mRNAs, thereby diminishing AM-evoked cAMP production. The suppression of these three mRNAs was unaffected by inhibiting NOS, protein kinase G, protein kinase A, superoxide formation or NF-kappaB activation.

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Citations

Jun 10, 2006·Cellular and Molecular Neurobiology·Masaru HondaMasami Niwa
Oct 19, 2011·Arthritis and Rheumatism·Marie-Dominique Ah KioonFrédéric Lioté
Oct 21, 2006·Molecular Endocrinology·Carrie GibbonsKathleen M Caron
Sep 20, 2007·American Journal of Physiology. Endocrinology and Metabolism·Alina SilaghiMichel Grino
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Benjamin UzanFrédéric Lioté

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