Tumor necrosis factor-alpha gene polymorphisms are associated with severity of acute graft-versus-host disease following matched unrelated donor bone marrow transplantation in children: a Pediatric Blood and Marrow Transplant Consortium study

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Rakesh K GoyalMark Atlas

Abstract

Tumor necrosis factor (TNF)-alpha plays a significant role in conditioning related toxicities and the development of acute graft-versus-host disease (aGVHD). TNF-alpha gene polymorphisms are associated with rejection after organ transplantation and aGVHD in matched related donor blood and marrow transplantation (BMT) recipients. Few studies have been published on unrelated donor BMT in the pediatric age group. In this study, we examined the relationship between specific polymorphisms in TNF pathway genes and the occurrence and severity of aGVHD. Recipient single-nucleotide polymorphisms (SNPs) in TNF-alpha and TNF receptor superfamily members 1A (TNFRSF1A) and 1B (TNFRSF1B) were investigated. In a multi-institutional Pediatric Blood and Marrow Transplant Consortium trial, a total of 180 pediatric patients (mean age, 11.0 years) were prospectively evaluated for clinical outcomes after matched unrelated donor BMT. All patients received myeloablative conditioning and two-drug GVHD prophylaxis with cyclosporine or tacrolimus, with methotrexate in the majority of patients. TNF-alpha genotypes were not correlated with the overall incidence of aGVHD. Significant associations were seen between TNF-alpha variant alleles and the severity...Continue Reading

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Citations

Feb 18, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Michelle KolbPrakash Satwani
Dec 5, 2012·British Journal of Haematology·Andrew C HarrisJohn E Levine
Oct 4, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Florence BettensJean-Marie Tiercy
Dec 25, 2010·Acta Microbiologica Et Immunologica Hungarica·Joseph G Sinkovics
Sep 25, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Joseph H AntinDaniel Weisdorf
Sep 7, 2016·Bone Marrow Transplantation·R K GoyalR E Ferrell
Oct 10, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Annekathrin HaberlandIngolf Schimke
Jul 22, 2018·Blood Advances·Carolina Martínez-LapercheUNKNOWN GVHD/Immunotherapy Committee of the Spanish Group for Hematopoietic Transplantation
May 11, 2019·International Journal of Environmental Research and Public Health·Sarah L WestGreg D Wells

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