PMID: 9548606Apr 21, 1998Paper

Tumor necrosis factor-alpha in isolated perfusion systems in the treatment of cancer: the Rotterdam preclinical-clinical program

Seminars in Surgical Oncology
E R ManusamaA M Eggermont

Abstract

The clinical success of the application of tumor necrosis factor-alpha (TNFalpha) in isolated limb perfusions in patients with advanced sarcomas, melanomas and other tumors has renewed the interest in this agent as an anticancer drug. At the Rotterdam Cancer Center, we have developed an interactive preclinical-clinical TNFalpha program that explores new methods to use TNFalpha in various settings. Regional organ perfusion models were developed and the effectivity of targeting of TNFalpha to the tumor by means of systemic administration of liposomes are tested. Furthermore various drugs and mechanisms that may enhance the activity of TNFalpha are under investigation. A summary of this comprehensive program is presented here.

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Citations

Oct 21, 1999·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J BickelsI Meller
Jan 25, 2000·Cancer Treatment Reviews·A J BremersC J van de Velde
Jun 22, 2000·International Journal of Cancer. Journal International Du Cancer·M J EhrkeE Mihich
Jan 21, 2006·Nature Reviews. Drug Discovery·David SchramaJürgen C Becker
Mar 12, 2009·Medical Oncology·Inès ZidiNidhal Ben Amor
Aug 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stefan BauerChristoph Renner
May 17, 2008·Molecular Cancer Therapeutics·Hui WangXiaoyuan Chen

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