Tumor necrosis factor-alpha in psoriasis and psoriatic arthritis: a clinical, genetic, and histopathologic perspective

Current Rheumatology Reports
David Kane, Oliver Fitzgerald

Abstract

The successful introduction of anti-tumor necrosis factor (TNF) therapies in psoriasis and psoriatic arthritis has sharpened considerable interest in this chronic and frequently disabling disease. Unlike the situation in rheumatoid arthritis, where anti-TNF therapies were introduced after years of painstaking research which confirmed a key proinflammatory role for TNF, the evidence for TNF having a key role in psoriatic arthritis has lagged behind. In this paper, the emerging immunohistochemical, genetic, and clinical literature relating to TNF's role in skin and joint manifestations of this disease is reviewed and areas for future research are suggested.

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Citations

May 17, 2006·Journal of Biomedical Science·Chi-Chen WeiMing-Shi Chang
Feb 15, 2005·Annals of the Rheumatic Diseases·D J VealeO FitzGerald
Nov 15, 2005·Annals of the Rheumatic Diseases·P RahmanD Gladman
Jul 28, 2005·Current Rheumatology Reports·David Kane
Mar 7, 2014·The Journal of Investigative Dermatology·Giuseppe MurdacaFrancesco Puppo
Sep 22, 2016·SpringerPlus·Radwa R El-TahanNoha El-Mashad
Jan 9, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·A MadejJ C Szepietowski
Jan 29, 2020·Biotechnology Progress·Kazem MashayekhiMojtaba Sankian
Apr 17, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Athina TrakakiGunther Marsche

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