PMID: 8613979Feb 1, 1995Paper

Tumor necrosis factor-alpha in serum of macaques during SIVmac251 acute infection

Journal of Medical Primatology
P ClayetteDominique Dormont

Abstract

TNF secretion was explored in sera during acute SIV-infection of cynomolgus macaques. A peak of TNF was detected in sera of animals in concomitance with SIV replication. Likewise, AZT treatment delayed and reduced peaks of viral replication and TNF production. Thus, SIVmac251-infected monkey could be an excellent model to explore the interdigitation existing between HIV and TNF in acute and chronic infection and to develop new therapeutic strategies that target the production of this cytokine or its inductive effects.

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Citations

May 29, 1998·Research in Virology·D BlondD Dormont
Feb 4, 1999·Journal of Colloid and Interface Science·E Bourgeat-Lami, J Lang
Mar 12, 2005·The Journal of Clinical Investigation·Christopher KornfeldMichaela C Müller-Trutwin

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