PMID: 8967361Apr 1, 1996Paper

Tumor necrosis factor-alpha-induced expression of heat shock protein 72 in adult feline cardiac myocytes

The American Journal of Physiology
M NakanoD L Mann

Abstract

Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that is elaborated in a myriad of cardiac disease states. Although the biological role for TNF-alpha in the adult heart is not known, a recent study in fetal myocardial cells has shown that this cytokine increases the synthesis of low-molecular-weight stress proteins. These findings suggested the interesting possibility that TNF-alpha might play a functional role in the adult heart by increasing the expression of stress proteins in cardiac myocytes. Accordingly, the purpose of this study was to determine whether TNF-alpha would modulate the expression of heat shock protein 72 (HSP 72), a stress protein that is thought to exert protective effects in the adult heart. Stimulation of adult feline cardiac myocytes with a range of TNF-alpha concentrations (10-1,000 U/ml) for 12 h showed that concentrations of TNF-alpha < or = 10 U/ml had no effect on HSP 72 expression: increased HSP 72 expression was detected 3 h following cytokine stimulation, peaked by approximately 12 h, and then returned toward baseline by 48 h. Additional studies indicated that stimulation of the type 1 TNF receptor was responsible for the increase in HSP 72 expression. In summary, these studi...Continue Reading

Citations

Dec 3, 2005·Cell Biology and Toxicology·J L LarabeeJ S Hanas
Oct 3, 2001·Physiological Reviews·L H SnoeckxG J Van Der Vusse
Aug 20, 2004·American Journal of Physiology. Heart and Circulatory Physiology·David EngelDouglas L Mann
Oct 13, 2006·World Journal of Gastroenterology : WJG·Vasilios PanterisDemetrios-Georgios Karamanolis
Dec 26, 2002·Annual Review of Physiology·Douglas L Mann
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·L SunA A Knowlton
Nov 11, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S Q JiM E Spurlock

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