PMID: 2494663Apr 1, 1989Paper

Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytes

Proceedings of the National Academy of Sciences of the United States of America
J W LowenthalW C Greene

Abstract

We have investigated the biochemical basis for the activation of interleukin 2 receptor alpha-subunit (IL-2R alpha) gene expression in primary human T lymphocytes by a cytokine (tumor necrosis factor alpha), a T-cell mitogen (phorbol 12-myristate 13-acetate), and the transactivator protein (Tax) from the type I human T-cell leukemia virus. Using in vivo transfection techniques specificially designed for these primary T cells in conjunction with in vitro gel retardation and DNA footprinting assays, we found that activation of the IL-2R alpha promoter by each of these agents involves the induction of nuclear proteins that specifically interact with a kappa B-like enhancer element (i.e., an element resembling the immunoglobulin kappa-chain enhancer sequence recognized by transcription factor NF-kappa B). DNA-protein crosslinking studies revealed that primary T cells express at least three different inducible DNA-binding proteins (50-55, 70-75, and 80-90 kDa) that specifically interact with this IL-2R alpha kappa B element.

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Citations

Jun 19, 1998·Journal of Cellular Biochemistry·K E DolterJ Yu
Feb 1, 1990·Journal of Molecular Recognition : JMR·P E Nielsen
May 1, 1991·Somatic Cell and Molecular Genetics·C J Frégeau, R C Bleackley
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Feb 14, 2006·Diabetes Technology & Therapeutics·Kevin A Deans, Naveed Sattar

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