Tumor necrosis factor-alpha is required for gastritis induced by Helicobacter felis infection in mice

Microbial Pathogenesis
Suguru HasegawaAkio Nakane

Abstract

Helicobacter pylori colonizes the gastric mucosa of human and causes chronic gastritis. The previous studies have demonstrated that gamma interferon (IFN-gamma) but not tumor necrosis factor-alpha (TNF-alpha) plays a critical role in pathogenesis of gastritis induced by H. pylori infection. In this study we investigated the induction of gastritis induced by H. felis infection in TNF-alpha-deficient mice, comparing with IFN-gamma-deficient mice. The scores of gastritis and epithelial changes of TNF-alpha-deficient mice and IFN-gamma-deficient mice were significantly lower than that of C57BL/6 mice. Moreover, the degrees of gastritis and epithelial changes of TNF-alpha-deficient mice were rather low compared with that of IFN-gamma-deficient mice. In spleen cell cultures stimulated with heat-killed H. felis, IFN-gamma production by TNF-alpha-deficient mice and TNF-alpha production by IFN-gamma-deficient mice were significantly reduced compared with those in C57BL/6 mice. These results suggested that TNF-alpha is involved in pathogenesis of gastritis induced by H. felis infection as IFN-gamma and that an interaction between TNF-alpha and IFN-gamma might be required in pathogenesis of gastritis induced by Helicobacter infection.

References

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Citations

Mar 1, 2013·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Raghvendra Raman MishraHari S Shukla
Dec 25, 2012·Infection and Immunity·Brian M GrayKathryn A Eaton
Feb 11, 2014·Clinics and Research in Hepatology and Gastroenterology·Nader BagheriHedayatollah Shirzad
Oct 14, 2014·Journal of Immunology Research·Lilia A CherdantsevaVyacheslav A Shkurupiy
May 9, 2007·Gastroenterology·Andrew S Giraud
Nov 13, 2010·FEMS Immunology and Medical Microbiology·Yinghui ZhaoJihui Jia
Sep 6, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Victoria G WeisJames R Goldenring

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