Tumor necrosis factor-alpha mediates osteopenia caused by depletion of antioxidants

Endocrinology
Chris J JaggerT J Chambers

Abstract

We recently found that estrogen deficiency leads to a lowering of thiol antioxidant defenses in rodent bone. Moreover, administration of agents that increase the concentration in bone of glutathione, the main intracellular antioxidant, prevented estrogen-deficiency bone loss, whereas depletion of glutathione by buthionine sulfoximine (BSO) administration provoked substantial bone loss. It has been shown that the estrogen-deficiency bone loss is dependent on TNFalpha signaling. Therefore, a model in which estrogen deficiency causes bone loss by lowering antioxidant defenses predicts that the osteopenia caused by lowering antioxidant defenses should similarly depend on TNFalpha signaling. We found that the loss of bone caused by either BSO administration or ovariectomy was inhibited by administration of soluble TNFalpha receptors and abrogated in mice deleted for TNFalpha gene expression. In both circumstances, lack of TNFalpha signaling prevented the increase in bone resorption and the deficit in bone formation that otherwise occurred. Thus, depletion of thiol antioxidants by BSO, like ovariectomy, causes bone loss through TNFalpha signaling. Furthermore, in ovariectomized mice treated with soluble TNFalpha receptors, thiol anti...Continue Reading

References

Mar 31, 1992·Biochemical and Biophysical Research Communications·B E BaxM Zaidi
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A JainA Meister
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J MårtenssonA Meister
Aug 1, 1994·The Journal of Cell Biology·M J SteinbeckM J Karnovsky
Jun 28, 2000·Proceedings of the National Academy of Sciences of the United States of America·N K ShevdeJ W Pike
Feb 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C RichmanS Mohan
Aug 11, 2001·Free Radical Biology & Medicine·N ModyL L Demer
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·C RoggiaR Pacifici
Feb 15, 2002·Endocrine Reviews·Johannes PfeilschifterHelmut Schatz
May 23, 2002·Recent Progress in Hormone Research·S C ManolagasR L Jilka
Jun 7, 2002·Endocrine Reviews·B Lawrence RiggsL Joseph Melton
Aug 30, 2002·Biochemical and Biophysical Research Communications·John J Haddad
Oct 25, 2002·Journal of Cellular Biochemistry·Hiroshi SamotoYorimasa Ogata
Sep 13, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L C GerstenfeldT A Einhorn

❮ Previous
Next ❯

Citations

May 25, 2013·BoneKEy Reports·Maria Almeida
Jul 12, 2007·The Journal of Biological Chemistry·Maria AlmeidaStavros C Manolagas
Oct 2, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Zil HayatullinaIma-Nirwana Soelaiman
May 4, 2006·The Journal of Clinical Investigation·M Neale Weitzmann, Roberto Pacifici
Jul 5, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Maria Almeida, Charles A O'Brien
Sep 13, 2007·Proceedings of the National Academy of Sciences of the United States of America·Francesco GrassiRoberto Pacifici
Aug 29, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Mouna Abdelrahman AbujaziaIma Nirwana Soelaiman
Dec 6, 2014·Oxidative Medicine and Cellular Longevity·Sudarat SungkamaneeWipawee Thukham-mee
May 30, 2008·Calcified Tissue International·So Young BuBrenda J Smith
Apr 11, 2013·Menopause : the Journal of the North American Menopause Society·Payal BhardwajMohan Lal Garg
Oct 26, 2010·Biological Trace Element Research·Hui LiuGuang-sheng Li
Oct 5, 2013·Biological Trace Element Research·Eun-Jin KimMi-Kyeong Choi
Jan 31, 2009·Aging Clinical and Experimental Research·Sheau C ChaiBahram H Arjmandi
May 7, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S H AhnG S Kim
Jul 6, 2010·Archives of Biochemistry and Biophysics·Roberto Pacifici
Oct 9, 2009·Trends in Molecular Medicine·Fabien WauquierYohann Wittrant
Aug 5, 2015·The Journal of Nutritional Biochemistry·Lu ZhaoMing Yin
Nov 6, 2007·Journal of Cellular Biochemistry·Ji Hae JunJeong-Hwa Baek
Aug 7, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R Pacifici
Jan 25, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Roberto Pacifici
Feb 22, 2011·Journal of Periodontal Research·C GalliG M Macaluso
Dec 10, 2014·Molecular Nutrition & Food Research·Leslie A NashWendy E Ward
Feb 6, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Pierre J Marie
Jun 23, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sridhar MuthusamiSrinivasan Narasimhan
Sep 13, 2015·Biological Trace Element Research·So Young BuMi-Kyeong Choi
Aug 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Tatiane OliveiraAnuradha Prakki
Dec 9, 2014·Autophagy·Marie NolletValérie Pierrefite-Carle
Nov 12, 2014·Journal of Medicinal Food·Lydia KaumeLatha Devareddy
Jul 6, 2014·Journal of Bone and Mineral Metabolism·Yuki IimuraNaomi Omi
Aug 30, 2014·Cellular and Molecular Life Sciences : CMLS·Katrin Schröder
Jun 10, 2016·Canadian Journal of Physiology and Pharmacology·Radoslaw Piotr RadzkiAgnieszka Radzka
Aug 4, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Joshua N Farr, Maria Almeida

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.