Tumor necrosis factor-alpha messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity

Annals of Neurology
P RieckmannS Poser

Abstract

We determined the cytokine messenger RNA (mRNA) expression pattern of blood mononuclear cells in 29 patients with relapsing-remitting multiple sclerosis every 4 weeks over a period of 12 months. During this period 27 relapses occurred in 14 patients (48%). Progression of disease activity as assessed by the occurrence of new lesions on nonenhancing T2-weighted magnetic resonance images of the head was detected in 12 (48%) of 25 patients. Using a semiquantitative polymerase chain reaction we demonstrated significant increases in tumor necrosis factor-alpha mRNA expression in peripheral blood mononuclear cells prior to a relapse. In 24 (85%) of 27 relapses increased tumor necrosis factor-alpha mRNA expression preceded clinical symptoms by 4 weeks. A similar pattern was observed for lymphotoxin mRNA expression. At the same time, transforming growth factor-beta and interleukin-10 mRNA levels declined. Fluctuations in the mRNA expression of tumor necrosis factor-alpha were also observed in 6 patients with stable disease who had active magnetic resonance scans on follow-up. No correlation of disease activity was observed with interleukin-1 beta, -4, or -6, inferferon gamma or endothelin-1 mRNA expression. From these data it can be con...Continue Reading

References

Mar 1, 1992·Archives of Neurology·R A Rudick, R M Ransohoff
Nov 1, 1991·Annals of Neurology·K SelmajA H Cross
Aug 15, 1991·The New England Journal of Medicine·M K Sharief, R Hentges
Nov 1, 1991·Journal of Neuroimmunology·Y Kuroda, Y Shimamoto
Aug 1, 1991·Neuropathology and Applied Neurobiology·C S Raine
Mar 1, 1991·The Journal of Clinical Investigation·K SelmajC F Brosnan
Nov 14, 1985·Nature·B Waksman
Mar 1, 1989·Immunology Today·D A Hafler, H L Weiner
Aug 1, 1989·The Journal of Experimental Medicine·F M HofmanJ E Merrill
Feb 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·W I McDonald
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Apr 1, 1993·Journal of the Neurological Sciences·C M Poser
Aug 1, 1993·Journal of the Neurological Sciences·M HubermanB Sredni
Jun 1, 1993·Annals of Neurology·H P Hartung

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Citations

Jun 9, 1999·Annals of Neurology·C L Karp
May 26, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Mona Abd el Fattah Nada, Dalia Ahmed Labib
Sep 13, 2013·Current Neurology and Neuroscience Reports·Erin E LongbrakeAnne H Cross
Oct 6, 2007·Molecular Neurobiology·Manuel Yepes
May 3, 2012·Molecular Neurobiology·Charlotte AngersteinUwe Klaus Zettl
Dec 31, 1995·Journal of Neuroimmunology·B HeJ Hillert
Nov 1, 1996·Clinical Neurology and Neurosurgery·J PhilippéJ Dereuck
Dec 31, 2003·Journal of Neuroimmunology·Samantha S SoldanRhonda R Voskuhl
Feb 21, 2004·Journal of Neuroimmunology·Stefan JungKlaus Toyka
Mar 31, 1998·Journal of Immunological Methods·N KruseP Rieckmann
Nov 1, 1996·Journal of the Neurological Sciences·M R BongioanniB Bergamasco
Apr 15, 1997·Journal of the Neurological Sciences·J DrulovićS Mesaros
Jul 1, 1997·Journal of the Neurological Sciences·K P WandingerH Kirchner
Dec 16, 1998·Journal of the Neurological Sciences·J ZhuG Hedlund
Sep 29, 1999·Journal of the Neurological Sciences·P AnnunziataG C Guazzi
Nov 14, 1997·Neuroscience and Biobehavioral Reviews·W PanA J Kastin
Feb 11, 2003·Journal of Neuroimmunology·N FloresS Ballester
Oct 1, 1996·Journal of Neuroimmunology·F NicolettiA Reggio
Jul 25, 2003·Brain Research. Molecular Brain Research·Bo FranzénIna Schuppe-Koistinen
Aug 27, 1998·Neuroscience Letters·J DrulovićV Pravica

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