Tumor necrosis factor-alpha messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity

Annals of Neurology
P RieckmannS Poser


We determined the cytokine messenger RNA (mRNA) expression pattern of blood mononuclear cells in 29 patients with relapsing-remitting multiple sclerosis every 4 weeks over a period of 12 months. During this period 27 relapses occurred in 14 patients (48%). Progression of disease activity as assessed by the occurrence of new lesions on nonenhancing T2-weighted magnetic resonance images of the head was detected in 12 (48%) of 25 patients. Using a semiquantitative polymerase chain reaction we demonstrated significant increases in tumor necrosis factor-alpha mRNA expression in peripheral blood mononuclear cells prior to a relapse. In 24 (85%) of 27 relapses increased tumor necrosis factor-alpha mRNA expression preceded clinical symptoms by 4 weeks. A similar pattern was observed for lymphotoxin mRNA expression. At the same time, transforming growth factor-beta and interleukin-10 mRNA levels declined. Fluctuations in the mRNA expression of tumor necrosis factor-alpha were also observed in 6 patients with stable disease who had active magnetic resonance scans on follow-up. No correlation of disease activity was observed with interleukin-1 beta, -4, or -6, inferferon gamma or endothelin-1 mRNA expression. From these data it can be con...Continue Reading


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Aug 15, 1991·The New England Journal of Medicine·M K Sharief, R Hentges
Nov 1, 1991·Journal of Neuroimmunology·Y Kuroda, Y Shimamoto
Aug 1, 1991·Neuropathology and Applied Neurobiology·C S Raine
Mar 1, 1991·The Journal of Clinical Investigation·K SelmajC F Brosnan
Nov 14, 1985·Nature·B Waksman
Mar 1, 1989·Immunology Today·D A Hafler, H L Weiner
Aug 1, 1989·The Journal of Experimental Medicine·F M HofmanJ E Merrill
Feb 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·W I McDonald
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Apr 1, 1993·Journal of the Neurological Sciences·C M Poser
Aug 1, 1993·Journal of the Neurological Sciences·M HubermanB Sredni
Jun 1, 1993·Annals of Neurology·H P Hartung

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