Tumor necrosis factor-alpha modulates the selective interference of hypnotics and sedatives to suppress N-formyl-methionyl-leucyl-phenylalanine-induced oxidative burst formation in neutrophils

Critical Care Medicine
M WeissE M Schneider

Abstract

To clarify whether tumor necrosis factor (TNF)-alpha modulates the inhibitory effect of clinically applied hypnotics and sedatives on neutrophil function. Prospective, randomized, controlled, dose response, in vitro study. A university research laboratory. Neutrophils from healthy human volunteers. Neutrophils were primed by incubation with TNF-alpha (25 ng/mL) for 15 mins. Subsequently, TNF-alpha-primed neutrophils were incubated with two concentrations of commercially available drug preparations and drug-free solutions, respectively. The following commercially available preparations of hypnotics and sedatives as well as their corresponding drug-free solutions were tested: methohexital, thiopental, midazolam, diazepam, etomidate, and propofol. The production of oxygen radicals was initiated by adding N-formyl-methionyl-leucyl-phenylalanine (FMLP) 10(-7) mol/L and detected by luminol-enhanced chemiluminescence measurements for 15 mins. Within the range of therapeutic plasma concentrations, only thiopental, diazepam, and propofol suppressed chemiluminescence of unprimed neutrophils. Additionally, propofol alone suppressed TNF-alpha-primed neutrophils. Hypnotics and sedatives were unable to suppress oxygen radical production of T...Continue Reading

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Citations

Jan 12, 1999·Mediators of Inflammation·M Mathy-HartertM Lamy
Jun 5, 2013·International Forum of Allergy & Rhinology·Tatyana PozharskayaAndrew P Lane
Apr 10, 2002·Critical Care Medicine·Paul E Marik, Gary P Zaloga
Mar 11, 2003·Critical Care Medicine·Gary P Zaloga, Paul Marik
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Dec 8, 2011·International Journal of Immunopathology and Pharmacology·F CardinaleR Bernardini

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