Tumor necrosis factor-alpha polymorphism and susceptibility to multiple sclerosis in the Iranian population

Iranian Red Crescent Medical Journal
Masoomeh Rahmanian, Mohammad Kargar

Abstract

Multiple sclerosis (MS) is an immune-mediated disease of polygenic etiology. Tumor necrosis factor-α (TNF-α) microsatellite as a proinflammatory cytokine is believed to play an important role in the etiology of this disease. The aim of this study was to investigate the association of TNF-α microsatellite sequence variation in patients with MS and its risk factor in the southern Iranian population. This polymorphism was investigated in an Iranian population of 163 native southern people [81 patients with MS according to the poser criteria and 82 healthy controls (HC) with the same age, sex, social, ethnical and geographical features (Hormozgan and Fars provinces)]. All the controls were nonimmunological, neurological patients. All the cases and controls were chosen randomly and genotyped for polymorphism of TNF-α microsatellite. The frequencies of TNF-α*11 (0.25, P < 0.005) and TNF-α*10 (P < 0.005) alleles increased in patients with MS compared with controls, showing a significant difference among the studied population. The current study adds evidence to the association of TNF-α gene polymorphism and MS in this southern south Iranian population which is consistent with the genetic analysis of MS in Europeans (GAMES) project rep...Continue Reading

References

Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Nov 1, 1995·Multiple Sclerosis : Clinical and Laboratory Research·M Sandberg-WollheimF Pociot
Jul 18, 2002·Multiple Sclerosis : Clinical and Laboratory Research·L G PalacioJ L Sánchez
Oct 25, 2003·Journal of Neuroimmunology·Stephen Sawcer, Alastair Compston
Oct 25, 2003·Journal of Neuroimmunology·M LaaksonenJ Ilonen
Oct 25, 2003·Journal of Neuroimmunology·Mehdi AlizadehUNKNOWN French Multiple Sclerosis Genetics Group
Oct 25, 2003·Journal of Neuroimmunology·Alexandra WeberFrauke Zipp
Oct 25, 2003·Journal of Neuroimmunology·Cecilia RajdaLászló Vécsei
Oct 25, 2003·Journal of Neuroimmunology·Aslaug JonasdottirJeffrey Gulcher
Oct 25, 2003·Journal of Neuroimmunology·Shirley HeggartyColin Graham
Oct 25, 2003·Journal of Neuroimmunology·Maria LiguoriPatricia Momigliano-Richiardi
Oct 25, 2003·Journal of Neuroimmunology·Hanne F HarboAnne Spurkland
Oct 25, 2003·Journal of Neuroimmunology·Bartosz BieleckiKrzysztof W Selmaj
Oct 25, 2003·Journal of Neuroimmunology·M SantosP Maciel
Oct 25, 2003·Journal of Neuroimmunology·Berta Martins SilvaAslaug Jonasdottir
Oct 25, 2003·Journal of Neuroimmunology·Francesca CoradduMaria Giovanna Marrosu
Oct 25, 2003·Journal of Neuroimmunology·Robert GoertschesUNKNOWN Spanish MS Genetics Group
Oct 25, 2003·Journal of Neuroimmunology·M EraksoyUNKNOWN Turkish Multiple Sclerosis Genetics Study Group
Aug 29, 2006·Journal of Neuroimmunology·UNKNOWN Games Collaborative GroupStephen Sawcer
Oct 31, 2008·Lancet·Alastair Compston, Alasdair Coles
Oct 30, 2009·Genes and Immunity·B A JohnsonJ R Oksenberg
May 26, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Mona Abd el Fattah Nada, Dalia Ahmed Labib
Mar 27, 2012·Metabolomics : Official Journal of the Metabolomic Society·Marek J NogaThomas Hankemeier

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Methods Mentioned

BETA
PCR

Software Mentioned

GAMES
SPSS

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