Tumor necrosis factor-alpha production-inhibiting activity of phthalimide analogues on human leukemia THP-1 cells and a structure-activity relationship study

Bioorganic & Medicinal Chemistry
H MiyachiY Hashimoto

Abstract

N-Substituted phthalimides (2-substituted 1H-isoindole-1,3-diones) were prepared and their inhibitory effects on tumor necrosis factor-alpha (TNF-alpha) production by human leukemia cell line THP-1 stimulated with 12-O-tetradecanoylphorbol 13-acetate (TPA) or okadaic acid (OA) were examined. A structure-activity relationship study of these phthalimide analogues revealed that their inhibitory effects on TPA- and OA-induced TNF-alpha production by THP-1 cells are well correlated to each other, i.e. they may involve the same target molecule(s). An analysis by the use of phthalimide analogue-immobilized affinity gels indicated the existence of several phthalimide-binding proteins in THP-1 cell extract.

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Citations

Jun 7, 2005·Bioorganic & Medicinal Chemistry Letters·Tomomi NoguchiYuichi Hashimoto
Mar 23, 2002·Bioorganic & Medicinal Chemistry Letters·Tomomi NoguchiYuichi Hashimoto
Jan 30, 2002·Bioorganic & Medicinal Chemistry·Yuichi Hashimoto
Apr 15, 2011·Journal of Medicinal Food·Lidia MoralesDolores Muñoz-Mingarro
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Chuan-Gang Fan, Ming-Zhi Song
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Zhi-Gang YaoAi-Xi Hu
Jul 18, 2001·Biological & Pharmaceutical Bulletin·T KitaY Hashimoto
Sep 3, 2003·Chemical & Pharmaceutical Bulletin·Mamiko SuizuYuichi Hashimoto
Apr 2, 2004·Chemical & Pharmaceutical Bulletin·Rumiko ShimazawaYuichi Hashimoto
Dec 2, 2006·Chemical & Pharmaceutical Bulletin·Takanori NakamuraYuichi Hashimoto
Apr 6, 2007·Chemical & Pharmaceutical Bulletin·Takanori NakamuraYuichi Hashimoto
Jul 2, 2011·Chemical & Pharmaceutical Bulletin·Kazunori MotoshimaKazuyuki Sugita
Sep 4, 2004·Biochemical Pharmacology·Eduardo Fernández-MartínezPablo Muriel
Oct 3, 2003·Antiviral Chemistry & Chemotherapy·Jan BalzariniAndrzej Orzeszko
Apr 6, 2005·Bioorganic & Medicinal Chemistry·Hiroko SanoHiroyuki Miyachi
Aug 13, 1999·Journal of Enzyme Inhibition·R ShimazawaY Hashimoto
Feb 18, 2010·Medicinal Research Reviews·Eleni Pontiki, Dimitra Hadjipavlou-Litina
Jun 8, 2000·Bioorganic & Medicinal Chemistry Letters·S SouY Hashimoto
Jun 26, 2007·Bioorganic & Medicinal Chemistry Letters·Shoukou LeeHiroyuki Miyachi
Aug 15, 2008·Bioorganic & Medicinal Chemistry·Alexander EilfeldMichael Gütschow

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