PMID: 2501120Jan 1, 1989Paper

Tumor necrosis factor-alpha regulates mRNA for urokinase-type plasminogen activator and type-1 plasminogen activator inhibitor in human neoplastic cell lines

Molecular and Cellular Endocrinology
B GeorgP A Andreasen

Abstract

Tumor necrosis factor-alpha (TNF-alpha) was found to induce type-1 plasminogen activator inhibitor (PAI-1) antigen in the human fibrosarcoma cell line HT-1080, and PAI-1 and urokinase-type plasminogen activator (u-PA) antigens in the human carcinoma cell line T-CAR1; tissue-type plasminogen activator (t-PA) antigen was not affected or slightly decreased. The effects in HT-1080 and T-CAR1 cells were preceded by increases in the cellular levels of the corresponding mRNAs. Cycloheximide caused an increase of PAI-1 mRNA in T-CAR1 cells, but not in HT-1080 cells; during this increase the relative abundance of the two PAI-1 mRNA species, of 2.3 kb and 3.4 kb, respectively, changed strongly in favor of the longer transcript. We conclude that TNF-alpha may affect proteolytic activity in the microenvironment of cells in malignant tumors by affecting gene expression of u-PA and PAI-1.

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Citations

Jan 1, 1990·Histochemistry·P KristensenK Danø
Jan 2, 1990·Molecular and Cellular Endocrinology·P A AndreasenS N Stacey
Nov 3, 2004·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·N Muthukumar
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Jul 1, 2004·Thrombosis Research·Shinzo MiyamotoHisao Ogawa
Jun 2, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Manjula PandeyFahumiya Samad
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Feb 1, 1992·International Journal of Cancer. Journal International Du Cancer·K SumiyoshiS Baba
Aug 15, 2002·The Journal of Surgical Research·Yuan-Ping HanWarren L Garner

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