PMID: 9419020Jan 7, 1998Paper

Tumor necrosis factor alpha (TNF-alpha) activates human adenoidal and cutaneous mast cells to histamine secretion

Immunology Letters
E Brzezińska-Błaszczyk, A Pietrzak

Abstract

It is widely known that mast cells and cytokine TNF-alpha are both involved in inflammatory reactions. Therefore, we have studied whether TNF-alpha can cause histamine secretion from human adenoidal and cutaneous mast cells. The experiments were performed in vitro on mast cells isolated from tissues by enzymatic dispersion technique. The results of our experiments have clearly shown that this cytokine stimulates mast cells to histamine release. TNF-alpha-induced histamine release was concentration- and time-dependent. Moreover, the release of histamine evoked by TNF-alpha was also dependent on reaction temperature and on glycolytic and oxidative cellular metabolism. We have concluded that TNF-alpha is a potent stimulus for mast cells to release histamine and that it induces histamine release via an active, secretory process.

References

Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Oct 1, 1992·American Journal of Respiratory Cell and Molecular Biology·Y OhkawaraT Takishima
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D B DubravecM L Rodrick
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L J WalshG F Murphy
Aug 1, 1991·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·I L BontaM W Fieren
Dec 1, 1991·Current Opinion in Immunology·S J GalliB K Wershil
Jul 1, 1990·American Journal of Respiratory Cell and Molecular Biology·K Schollmeier
Nov 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H Salari, M Chan-Yeung

❮ Previous
Next ❯

Citations

Feb 27, 1999·Current Opinion in Immunology·S J GalliC S Lantz
May 11, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·E Brzezińska-BłaszczykA Pietrzak
Dec 7, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ewa Brzezińska-BłaszczykAnna H Misiak-Tłoczek
Nov 17, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Peter Bradding, Greer Arthur
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·William R CowardMartin K Church

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
E Brzezińska-BłaszczykA Pietrzak
Proceedings of the American Thoracic Society
Dennis Shusterman
Archives of Dermatological Research
E Brzezińska-Błaszczyk, A Zalewska
© 2021 Meta ULC. All rights reserved