Tumor necrosis factor and immune interferon synergistically induce cytochrome b-245 heavy-chain gene expression and nicotinamide-adenine dinucleotide phosphate hydrogenase oxidase in human leukemic myeloid cells

The Journal of Clinical Investigation
M A CassatellaG Trinchieri

Abstract

Recombinant tumor necrosis factor (rTNF) and rIFN-gamma induce in the human leukemia cell lines HL-60, ML3, and U937 the accumulation of transcripts of the X chromosome-linked chronic granulomatous disease (X-CGD) gene, encoding the 91-kD heavy chain of cytochrome b-245, a component of the NADPH oxidase of phagocytic cells. The gene is induced within 6 h by either cytokine, and its accumulation is observed upon induction with rIFN-gamma up to 5 d. The combined effect of the two cytokines is more than additive. rIFN-gamma also induces accumulation of X-CGD mRNA in immature myeloid cells from peripheral blood of chronic myeloid leukemia (CML) patients, whereas rTNF has almost no effect. The cells from CML patients constitutively express TNF mRNA, suggesting that endogenously produced TNF may play a role in the effect of rIFN-gamma on these cells. rTNF induces X-CGD gene expression in the myeloid cell lines acting, at least in part, at the transcriptional level, as shown in nuclear run-on experiments. The gene encoding the 22-kD light chain of cytochrome b-245 is constitutively expressed in the human myeloid cell lines and the accumulation of its transcripts is affected by neither rTNF nor rIFN-gamma, rTNF and rIFN-gamma synergist...Continue Reading

References

May 15, 1976·International Journal of Cancer. Journal International Du Cancer·C Sundström, K Nilsson
Mar 15, 1988·Biochemical and Biophysical Research Communications·J Balsinde, F Mollinedo
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P E NewburgerS H Orkin
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R L BaehnerS H Orkin
Jun 30, 1987·Biochemical and Biophysical Research Communications·J F ParkinsonT G Gabig
Aug 14, 1986·Biochemical and Biophysical Research Communications·G BertonF Rossi
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M KrönkeK Pfizenmaier
Jan 20, 1988·Biochimica Et Biophysica Acta·C A ParkosA J Jesaitis
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C A ParkosS H Orkin
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T CollinsJ S Pober
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P DefilippiJ Content
Sep 27, 1986·Journal of Immunological Methods·M A CassatellaG Berton
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A M MichelsonS H Orkin
Oct 1, 1983·The Journal of Experimental Medicine·B PerussiaG Trinchieri
Dec 1, 1982·The Journal of Experimental Medicine·P S SteegJ J Oppenheim

❮ Previous
Next ❯

Citations

Aug 12, 1983·Journal of Immunological Methods·B Freundlich, N Avdalovic
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·P BaronM A Cassatella
Jun 1, 2011·The Journal of Experimental Medicine·Erin E ZollerMichael B Jordan
Jan 1, 1997·Annual Review of Immunology·U BoehmJ C Howard
May 5, 2010·The American Journal of Tropical Medicine and Hygiene·Rajiv KumarSteven G Reed
Mar 24, 2006·Biochemical and Biophysical Research Communications·Caroline BasoniIjsbrand M Kramer
Jan 13, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·J D MarshallG Trinchieri
Oct 17, 2001·Developmental and Comparative Immunology·N F NeumannM Belosevic
Aug 2, 2003·International Immunopharmacology·Heiko Mühl, Josef Pfeilschifter
Jul 31, 1990·Biochemical and Biophysical Research Communications·P BellaviteJ V Bannister
Oct 4, 2003·Journal of Leukocyte Biology·Kate SchroderDavid A Hume
Jan 10, 2002·The Journal of Biological Chemistry·Atsushi KumatoriMichio Nakamura
Aug 21, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Linda A Tephly, A Brent Carter
Sep 16, 2020·BMC Genomics·José Ricardo ParreiraAndré Martinho de Almeida
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicola TamassiaMarco A Cassatella
Mar 1, 1994·FEMS Immunology and Medical Microbiology·J A QuayleS W Edwards

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.