Tumor necrosis factor and interferon activity in the circulation of calves after repeated injection of low doses of lipopolysaccharide

Veterinary Immunology and Immunopathology
K BieniekM Kandefer-Szerszeñ

Abstract

The effect of two intravenous (i.v.) injections of low doses of lipopolysaccharide (LPS)(0.1 microgram/kg of body weight) administered at 7-day intervals on the systemic release of tumor necrosis factor (TNF) and interferon (IFN), on the rectal temperature, breathing and heart rate, and on packed cell volume (PCV), plasma glucose concentration, white blood cell (WBC) counts in 3-week-old calves, was estimated. The first injection of LPS caused a significant increase in breathing and heart rate, rectal temperature, prolonged hypoglycemia and leukopenia, but no significant changes in PCV were observed. TNF and IFN activity peaked at 2 h after LPS injection and disappeared from circulation by 4 h and 5 h, respectively. After the second injection of LPS, the reaction of calves was similar to that observed after the first injection, however, the breathing rate and TNF systemic production were significantly reduced. The results obtained indicate that a low dose of LPS leads to the development of 'late' tolerance manifested by hyporeactivity to TNF production but with maintained responsivity to IFN production, pyrogenic, hypoglycemic and leukemic response to the second injection of LPS. In conclusion, these results demonstrate that th...Continue Reading

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Citations

Mar 30, 2010·Cell Stress & Chaperones·Elisabetta CatalaniNicola Lacetera
May 7, 2004·Veterinary Immunology and Immunopathology·Sirri AvkiAyhan Unsal
Dec 24, 2014·Veterinary Immunology and Immunopathology·Elke PlessersSiska Croubels
Jul 27, 2011·Environmental Toxicology and Pharmacology·Rafał PorębaRyszard Andrzejak
Nov 23, 2016·Innate Immunity·Jeffery A CarrollPhillip A Lancaster
Feb 28, 2019·Journal of Veterinary Emergency and Critical Care·Diego E GomezJ Trenton McClure
May 30, 2013·Journal of Biosocial Science·Tomasz HanćJoachim Cieślik
Aug 5, 2020·Journal of Dairy Science·C Kent-DennisG B Penner
Jan 4, 2017·Journal of Dairy Science·S K KvideraL H Baumgard
Apr 2, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eugene NalivaikoWilliam W Blessing

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