PMID: 9185077Apr 1, 1997Paper

Tumor necrosis factor-beta in human pregnancy and labor

Journal of Reproductive Immunology
N LahamGregory E Rice

Abstract

The aims of this study were to determine tumor necrosis factor-beta (TNF-beta) concentration profiles in peripheral venous plasma and amniotic fluid during pregnancy and at the time of labor and to characterise TNF-beta mRNA expression and TNF-beta release from human gestational tissues. In addition, we investigated the expression of TNF-beta binding protein, lymphotoxin-beta (LT-beta), in human gestational tissues. The mean (+/-S.E.M.) TNF-beta concentrations in maternal plasma (TIL, 78 +/- 12 pg/ml, n = 7 vs. TNIL, 304 +/- 88 pg/ml, n = 7) and amniotic fluid (TIL, 8 +/- 5 pg/ml, n = 6 vs. TNIL, 73 +/- 20 pg/ml, n = 20) were significantly (P < 0.05) decreased in association with term labor-onset (TIL) compared to term not-in-labor (TNIL). TNF-beta concentration in maternal plasma and amniotic fluid did not change significantly either with preterm labor (PIL), or during pregnancy. Group-matched comparison of maternal plasma and amniotic fluid TNF-beta concentrations demonstrated that amniotic fluid TNF-beta concentrations were 6-8 fold lower than maternal plasma TNF-beta concentrations. Furthermore, no detectable TNF-beta was secreted from cultured human amniotic, choriodecidual and placental explants. Although, TNF-beta mRNA w...Continue Reading

References

Aug 1, 1992·Journal of Reproductive Immunology·R AustgulenT Espevik
Jun 1, 1992·Current Opinion in Immunology·N H Ruddle
Sep 1, 1992·European Journal of Immunology·G ValenteG Garotta
Jul 1, 1990·Journal of Reproduction and Fertility·G ChaouatT G Wegmann
Jul 1, 1990·American Journal of Reproductive Immunology : AJRI·R KinskyG Chaouat
Jan 1, 1989·Advances in Immunology·T R Mosmann, R L Coffman
Aug 1, 1993·Immunology Letters·K RieneckK Bendtzen
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May 1, 1993·Placenta·M D MitchellD J Dudley

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Citations

Dec 19, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·D C VoonL J Abraham
Sep 14, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroTinnakorn Chaiworapongsa
Sep 26, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Valerie SteckleAlan Bocking
May 17, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jacek R Wilczyński

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