PMID: 18411185Nov 1, 1991Paper

Tumor necrosis factor, cytokines, and the hyperlipidemia of infection

Trends in Endocrinology and Metabolism : TEM
C Grunfeld, K R Feingold

Abstract

The hypertriglyceridemia of infection is produced by many of the cytokines that regulate the immune response, including the tumor necrosis factors, interleukin-1, interleukin-6, and the interferons. In rodents, this hypertriglyceridemia is primarily due to the ability of these cytokines to stimulate hepatic lipogenesis and very low density lipoprotein production without causing significant changes in adipose tissue lipoprotein lipase or triglyceride clearance. Induction of hypertriglyceridemia is not directly linked to the syndrome of wasting. Rather, the increase in hepatic production of lipoproteins is part of the acute-phase response and may contribute to host defense.

References

Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J C LeongJ A Levy
May 1, 1976·The Journal of Infectious Diseases·R L KaufmannW R Beisel
Jan 1, 1975·Annual Review of Medicine·W R Beisel
Jan 1, 1991·Biotherapy·C Grunfeld, K R Feingold
Apr 1, 1990·Proceedings of the Society for Experimental Biology and Medicine·B J MullenR J Martin
Sep 1, 1990·The Journal of Clinical Investigation·H W HarrisJ H Rapp
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J S PattonC Grunfeld
Jan 1, 1989·Advances in Immunology·C A Dinarello
Jun 1, 1989·Cancer Letters·S M Mahony, M J Tisdale
Jul 1, 1989·The Journal of Clinical Investigation·M K HellersteinC A Dinarello
Oct 1, 1988·The Journal of General Virology·J SernatingerJ A Levy
Jan 1, 1989·Annals of Surgery·H R MichieD W Wilmore
Feb 20, 1989·Biochimica Et Biophysica Acta·T Chajek-ShaulY Stein
Oct 1, 1988·The Journal of Clinical Investigation·H F StarnesM F Brennan
Mar 1, 1988·The Journal of Experimental Medicine·K J TraceyA Cerami
Jun 1, 1988·The Journal of Experimental Medicine·S H SocherD Martinez
Dec 1, 1987·The American Journal of Physiology·L L MoldawerK G Lundholm
Jan 1, 1973·The Journal of Infectious Diseases·J C Guckian

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Citations

Feb 23, 1995·Molecular and Cellular Biochemistry·J López-SorianoF J López-Soriano
Jan 1, 1996·Nutrition·C Grunfeld, K R Feingold
Mar 1, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·R W JohnsonK W Kelley
Jul 30, 1992·The New England Journal of Medicine·C Grunfeld, K R Feingold
Oct 25, 2011·Critical Care : the Official Journal of the Critical Care Forum·Lies LangoucheGreet Van den Berghe
Nov 9, 2012·Critical Care Medicine·Mirna B Marques, Lies Langouche
Mar 10, 2010·Journal of Internal Medicine·R H StraubG Pongratz
Jan 1, 1993·Scandinavian Journal of Infectious Diseases·W Liao, C H Florén
Jan 23, 1999·The Journal of Nutrition·M J Tisdale
May 6, 2010·American Journal of Respiratory and Critical Care Medicine·Lies LangoucheGreet Van den Berghe
Aug 1, 1993·Infection and Immunity·T E ReadJ H Rapp
Sep 1, 1995·Infection and Immunity·T van der PollS F Lowry

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