Tumor necrosis factor genetic polymorphisms and response to antiviral therapy in patients with chronic hepatitis C

The American Journal of Gastroenterology
Hugo R RosenSunwen Chou

Abstract

Hepatitis C virus (HCV) is the major causal agent of non-A, non-B hepatitis and the leading indication for liver transplantation worldwide. The emerging field of immunogenetics has confirmed the significant role of heritability in host immune responses to infectious pathogens. Both the major and non-major histocompatibility complex genes are increasingly identified as candidate genes hypothesized to influence the susceptibility to, or the course of, a particular disease. We hypothesized that polymorphisms within the major histocompatibility complex class III region that encode for tumor necrosis factors (TNF)-alpha and TNF-beta might be predictive of response to antiviral therapy in patients with chronic hepatitis C. A total of 155 subjects, including 110 HCV-seropositive individuals undergoing antiviral therapy and 45 ethnically similar HCV-negative controls, were studied. The HCV-positive patients had undergone antiviral treatment with either interferon monotherapy (n = 73) or in combination with ribavirin (n = 37) and were categorized as either nonresponders, sustained responders, or relapsers. Sixty (55%) patients had genotype 1 (1a or 1b). Genomic DNA was extracted, followed by polymerase chain reaction amplification and s...Continue Reading

References

Jul 1, 1992·Gastroenterology·H TilgC Huber
Nov 1, 1995·The Journal of Experimental Medicine·M CabreraJ M Blackwell
Feb 1, 1995·Seminars in Liver Disease·Z D Goodman, K G Ishak
Jan 1, 1996·Immunogenetics·P A ZimmermanT B Nutman
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·A G WilsonG W Duff
Apr 1, 1997·Molecular Immunology·K M KroegerL J Abraham
Nov 20, 1998·The New England Journal of Medicine·T J Liang
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M AstiE M Silini
Jul 28, 1999·Seminars in Liver Disease·S L Friedman
Jul 28, 1999·Seminars in Liver Disease·M J Koziel
Dec 30, 1999·Clinical Biochemistry·M G NeumanP Marcellin
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C L ThioM Carrington
Mar 7, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L J YeeR A Kaslow
Apr 9, 2001·Clinics in Liver Disease·A Ahmed, E B Keeffe
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hugo R RosenDavid J Hinrichs

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Citations

Sep 15, 2011·Immunotherapy·Aarthi Chary, Mark Holodniy
Feb 28, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Matthias J BahrRalf Lichtinghagen
Aug 19, 2007·Experimental Dermatology·Marco CarrozzoAntonio Amoroso
Sep 26, 2015·Genetic Testing and Molecular Biomarkers·Juliana B OliveiraAna Lúcia C Domingues
Sep 29, 2004·Trends in Biotechnology·Emil ChuangRobert T Sarisky
Jul 28, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Tzy-Yen ChenHui-Ling Chiou
Feb 20, 2004·Genes and Immunity·J-P BayleyC L Verweij
Apr 23, 2004·Genes and Immunity·L J Yee
Sep 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hermann E WasmuthFrank Lammert
Apr 19, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Saad F JazrawiHugo R Rosen
Nov 28, 2007·Journal of Medical Virology·Fernanda Albuquerque PereiraMitermayer Galvão Reis
Oct 5, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Srunthron AkkarathamrongsinMasashi Mizokami
Feb 1, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Pam KimballRobert A Fisher
Jul 26, 2008·Molecular Diagnosis & Therapy·Julie R JonssonElizabeth E Powell
Feb 25, 2015·Tissue Antigens·R BuchananS I Khakoo
Apr 15, 2003·The Journal of General Virology·Michael FreseRalf Bartenschlager
Mar 25, 2017·Molecular Medicine Reports·Zehui Yan, Yuming Wang

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