PMID: 3139418May 1, 1988Paper

Tumor necrosis factor in experimental cancer regression with alphatocopherol, beta-carotene, canthaxanthin and algae extract

European Journal of Cancer & Clinical Oncology
G Shklar, J L Schwartz

Abstract

Regression of established hamster buccal pouch carcinoma has recently been demonstrated in association with an induction of tumor necrosis factor alpha in macrophages. Regression of hamster buccal pouch tumors has also been demonstrated following the local injection of alphatocopherol, canthaxanthin and an extract of Spirulina-Dunaliella algae. The current study demonstrates that cancer regression is also accompanied by a significant induction of tumor necrosis factor in macrophages in the tumor area, suggesting a possible mechanism of tumor destruction. One hundred and forty young, male adult hamsters were divided into seven equal groups of 20 animals. Epidermoid carcinomas were induced in right buccal pouches by 14 weeks of painting, three times per week, of a 0.5% solution of 7,12-dimethylbenz(a)anthracene. Groups 1 and 2 were untreated and sham injected controls. Groups 3-7 had injected twice weekly into the right buccal pouches 0.1 ml (1.9 mg/ml of 13-cis-retinoic acid, canthaxanthin, algae extract, beta-carotene and alphatocopherol. After 4 weeks the tumors in groups 3-7 demonstrated varying degrees of regression and the animals were sacrificed and the right buccal pouches excised. Tumor necrosis factor alpha (TNF-alpha) ...Continue Reading

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Citations

Jan 1, 1994·Journal of Cellular Biochemistry. Supplement·G J KelloffC C Sigman
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Jan 1, 1994·Cancer Chemotherapy and Pharmacology·B A TeicherD Northey
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Jan 1, 1995·European Journal of Cancer. Part B, Oral Oncology·T Tanaka
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Aug 1, 1995·Critical Reviews in Oncology/hematology·B A Teicher
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Jan 1, 1993·Nutrition and Cancer·D P TricklerJ L Schwartz
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May 28, 1993·Annals of the New York Academy of Sciences·J L SchwartzS Zhao
Feb 6, 2004·Biological & Pharmaceutical Bulletin·Yue-Hwa ChenHsiao-Ting Wu
Dec 24, 2005·Phytotherapy Research : PTR·Mahmood KhanVijay Kumar Kutala
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Nov 24, 2017·Antioxidants·Christian GalassoClementina Sansone
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