Tumor necrosis factor in the heart

The American Journal of Physiology
D R Meldrum

Abstract

The heart is a tumor necrosis factor (TNF)-producing organ. Both myocardial macrophages and cardiac myocytes themselves synthesize TNF. Accumulating evidence indicates that myocardial TNF is an autocrine contributor to myocardial dysfunction and cardiomyocyte death in ischemia-reperfusion injury, sepsis, chronic heart failure, viral myocarditis, and cardiac allograft rejection. Indeed, locally (vs. systemically) produced TNF contributes to postischemic myocardial dysfunction via direct depression of contractility and induction of myocyte apoptosis. Lipopolysaccharide or ischemia-reperfusion activates myocardial P38 mitogen-activated protein (MAP) kinase and nuclear factor kappa B, which lead to TNF production. TNF depresses myocardial function by nitric oxide (NO)-dependent and NO-independent (sphingosine dependent) mechanisms. TNF activation of TNF receptor 1 or Fas may induce cardiac myocyte apoptosis. MAP kinases and TNF transcription factors are feasible targets for anti-TNF (i.e., cardioprotective) strategies. Endogenous anti-inflammatory ligands, which trigger the gp130 signaling cascade, heat shock proteins, and TNF-binding proteins, also control TNF production and activity. Thus modulation of TNF in cardiovascular disea...Continue Reading

References

Feb 1, 1992·Circulation Research·G J Gross, J A Auchampach
Apr 3, 1992·Science·D P CerrettiL A Cannizzaro
Jul 1, 1992·The Journal of Surgical Research·W ErtelI H Chaudry
Oct 23, 1992·Science·T KishimotoT Taga
Aug 1, 1992·Cardiovascular Research·D M Walker, D M Yellon
Jun 1, 1992·Immunological Reviews·C A Dinarello
Sep 1, 1992·The Journal of Clinical Investigation·B P GiroirB Beutler
May 1, 1992·Journal of Molecular and Cellular Cardiology·J M BrownA H Harken
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J E GershenwaldL L Moldawer
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S L WeinsteinA L DeFranco
Jan 1, 1991·Progress in Lipid Research·R N Kolesnick
Aug 1, 1990·Annals of Surgery·J M BrownJ B Sharefkin
Jul 26, 1990·The New England Journal of Medicine·B LevineM Packer
Aug 1, 1990·The Journal of Surgical Research·D D BensardA H Harken
Jan 1, 1990·Journal of Molecular and Cellular Cardiology·R D LasleyR M Mentzer
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J M BrownJ E Repine
Sep 1, 1990·The Journal of Clinical Investigation·P A SobotkaJ X Thomas
Jan 1, 1989·Advances in Immunology·C A Dinarello
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T GulickG F Schreiner
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J M BrownJ E Repine
Mar 1, 1988·Journal of Applied Physiology·F L GlauserR P Fairman
Jun 1, 1986·The Journal of Experimental Medicine·C A DinarelloJ V O'Connor
Feb 12, 1987·The New England Journal of Medicine·B Beutler, A Cerami
Oct 24, 1986·Science·K J TraceyJ D Albert
May 1, 1970·The American Journal of Physiology·A M Lefer, J Martin
Apr 1, 1984·Annals of Internal Medicine·M M ParkerJ E Parrillo

❮ Previous
Next ❯

Citations

Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Deborah L CarlsonBrett P Giroir
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael A ZimmermanAlden H Harken
Feb 1, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Ulrich HofmannAndreas W Bonz
Dec 26, 2002·Annual Review of Physiology·Douglas L Mann
Mar 26, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Andreas SkyschallyGerd Heusch
May 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Peter D ConstableWanda M Haschek
Jan 15, 2004·American Journal of Physiology. Endocrinology and Metabolism·Peipei Wang, John C Chatham
Aug 18, 2006·Basic Research in Cardiology·Andreas SkyschallyGerd Heusch
May 27, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Meijing WangDaniel R Meldrum
Nov 23, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Meijing WangDaniel R Meldrum
Aug 24, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Troy A MarkelDaniel R Meldrum
Jan 11, 2008·American Journal of Physiology. Cell Physiology·Dan ShanJohn C Chatham
Aug 7, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Nancy C MossCraig H Selzman
Jul 19, 2008·Shock·Nathan M NovotnyDaniel R Meldrum
May 12, 2009·American Journal of Physiology. Heart and Circulatory Physiology·David B MurrayJoseph S Janicki
Nov 26, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Laura A A GilliamMichael B Reid
Dec 17, 2010·World Journal of Cardiology·Mozow Y Zuidema, Cuihua Zhang
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·B ChandrasekarG L Freeman
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J W HortonB Sanders
Jan 3, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·M FujitaR J Mason
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·K DetmerW H Newman
Sep 13, 2002·Microscopy Research and Technique·Teruhiko OkadaHarumichi Seguchi
Feb 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Gary WrightTerry B Rogers
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K K MeldrumA L Burnett
Jan 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Ricardo M GomezLeonor Sterin-Borda
Jan 17, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert B FelderAlan Kim Johnson
Feb 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S B HaudekB P Giroir
Jan 28, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paul R CrisostomoDaniel R Meldrum
Jun 28, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Gentzon HallTerry B Rogers
Sep 16, 2004·American Journal of Physiology. Endocrinology and Metabolism·Meijing WangDaniel R Meldrum
Jan 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Kirstan K MeldrumAlden H Harken
Oct 13, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Jiangning TanYansheng Du
Oct 28, 2004·American Journal of Physiology. Renal Physiology·R MisseriK K Meldrum
Feb 20, 2007·American Journal of Physiology. Heart and Circulatory Physiology·David K GloverGeorge A Beller
Mar 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·María Fernández-VelascoCarmen Delgado
Aug 7, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Meijing WangDaniel R Meldrum
Aug 30, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Paul R CrisostomoDaniel R Meldrum
Sep 23, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jing TanJureta W Horton
Nov 22, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Jureta W HortonD Jean White
Oct 14, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Zequan YangBrent A French
Aug 12, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Lynetta J JobeJoseph S Janicki
Jan 28, 2006·Heart and Vessels·Gokcen OrhanSerap Aykut Aka
Jul 10, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Shuzhuang LiXin L Ma
Apr 15, 2008·American Journal of Physiology. Heart and Circulatory Physiology·K ShivakumarE G Lakatta
Feb 23, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Aaron M AbarbanellDaniel R Meldrum
May 17, 2012·Cardiovascular Drugs and Therapy·Sreejit Parameswaran, Rajendra K Sharma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
C B CairnsA Banerjee
Pharmacological Research : the Official Journal of the Italian Pharmacological Society
R Ferrari
© 2022 Meta ULC. All rights reserved