Tumor necrosis factor-inducing activities of Cryptococcus neoformans components.

Infection and Immunity
D DelfinoG Teti

Abstract

Cryptococcus neoformans-induced tumor necrosis factor alpha (TNF-alpha) production may lead to increased human immunodeficiency virus replication in patients with AIDS. In order to identify cryptococcal components that are predominantly responsible for stimulating TNF production, various concentrations of glucuronoxylomannan (GXM), galactoxylomannan (GalXM), mannoproteins (MP), and alpha(1-3) [corrected] glucan were added to whole-blood cultures. All of the cryptococcal components tested, as well as whole heat-killed cryptococci, were capable of inducing TNF-alpha release in a dose-dependent manner. MP were significantly more potent than any of the other cryptococcal components tested or heat-killed cryptococci in stimulating TNF-alpha production (P < 0.05). GXM, in contrast, was significantly less potent in this activity than either GalXM or MP (P < 0.05). As little as 0.5 microg of MP per ml was sufficient to produce moderate but significant elevations of TNF-alpha release. Maximal MP-induced TNF-alpha levels were similar to those induced by Salmonella enteritidis lipopolysaccharide, our positive control. Further experiments using isolated leukocytes suggested that monocytes were the cell population mainly responsible for TNF...Continue Reading

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Citations

Feb 24, 2001·Medical Mycology·A Vecchiarelli
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·N LendvaiA Casadevall
Apr 9, 2001·Infection and Immunity·D PietrellaA Vecchiarelli
Sep 24, 2004·European Journal of Clinical Investigation·P M EllerbroekF E J Coenjaerts
Apr 14, 2004·Mycoses·Cornelia SpethReinhard Würzner
Aug 19, 2008·Mycoses·Cornelia SpethCornelia Lass-Flörl
Jan 19, 2016·Frontiers in Cellular and Infection Microbiology·Makoto UraiYoshitsugu Miyazaki
Feb 17, 2005·European Journal of Immunology·Carmelo BiondoGiuseppe Mancuso
Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S ShohamS M Levitz
Nov 8, 2018·Scientific Reports·Isabel Ferreira LaRocque-de-FreitasCelio Geraldo Freire-de-Lima

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