Tumor necrosis factor inhibitor-associated dermatomyositis.

Archives of Dermatology
Rachel KleinJonathan Dunham

Abstract

Dermatomyositis is an autoimmune disease of unknown etiology characterized by inflammation of the skin and muscles. Several medications have been implicated in the development of dermatomyositis; however, the disease has rarely been linked to the use of tumor necrosis factor (TNF) inhibitors. We report 4 cases of dermatomyositis that developed or were exacerbated by exposure to the TNF inhibitors etanercept and adalimumab. Observation Four patients with symptoms of inflammatory arthritis were treated with TNF inhibitors for a duration ranging from 2 months to 2 years. All 4 patients developed symptoms consistent with dermatomyositis, including inflammatory rash and muscle weakness. Their symptoms persisted after discontinuation of the treatment with the TNF inhibitors but responded to treatment with corticosteroids and immunosuppressive medications. Tumor necrosis factor inhibitors have been associated with the onset of a number of autoimmune disorders, most commonly vasculitis and a lupuslike syndrome. Rarely have they been associated with dermatomyositis. The 4 cases reported herein indicate that TNF inhibitor use can be associated with either induction or exacerbation of dermatomyositis.

References

Dec 1, 1999·Inflammatory Bowel Diseases·S Romagnani
Jan 1, 2003·Rheumatic Diseases Clinics of North America·Ingrid E Lundberg, Maryam Dastmalchi
May 26, 2004·Best Practice & Research. Clinical Rheumatology·Richard D Sontheimer
Aug 7, 2004·Annals of the Rheumatic Diseases·C ErikssonS Rantapää-Dahlqvist
Apr 27, 2005·Annals of Neurology·Steven A GreenbergAnthony A Amato
Sep 9, 2006·The Journal of Rheumatology·Florenzo IannoneGiovanni Lapadula
Dec 2, 2006·Arthritis and Rheumatism·Harald A Hall, Bernard Zimmermann
Jul 17, 2007·Medicine·Manuel Ramos-CasalsMunther A Khamashta
Jul 16, 2008·Journal of the American Academy of Dermatology·Anne M Seidler, Alice B Gottlieb
Nov 26, 2008·Best Practice & Research. Clinical Rheumatology·Manuel Ramos-CasalsMunther A Khamashta
May 7, 2009·Rheumatology·Emma L WilliamsChristopher J Edwards

❮ Previous
Next ❯

Citations

Feb 2, 2012·Inflammatory Bowel Diseases·Archana V PatelRichard P MacDermott
Aug 30, 2012·Zeitschrift für Rheumatologie·A Rubbert-Roth, H-F Petereit
Jun 12, 2013·American Journal of Clinical Dermatology·Alisa N FemiaJeffrey P Callen
Sep 20, 2011·Current Opinion in Rheumatology·Heřman F Mann, Jiří Vencovský
Sep 8, 2012·Current Opinion in Rheumatology·Rohit Aggarwal, Chester V Oddis
Aug 8, 2012·Therapeutic Advances in Musculoskeletal Disease·David J Gazeley, Mary E Cronin
Oct 8, 2011·PloS One·Xiaoren TangSalomon Amar
Jun 7, 2013·Indian Dermatology Online Journal·Keshavmurthy A AdyaAparna Palit
Apr 17, 2013·Clinical Rheumatology·Rosario PelusoMatteo Nicola Dario Di Minno
Aug 12, 2014·Gastroenterology Clinics of North America·Joseph D Feuerstein, Adam S Cheifetz
Jan 13, 2011·JAMA : the Journal of the American Medical Association·Lisa G Rider, Frederick W Miller
May 26, 2016·Respiratory Medicine Case Reports·Ying ZhouRobert P Baughman
Aug 28, 2015·Expert Review of Clinical Immunology·Siamak Moghadam-KiaChester V Oddis
Nov 5, 2013·Rheumatic Diseases Clinics of North America·Lisa G RiderOlcay Y Jones
Dec 15, 2012·Joint, Bone, Spine : Revue Du Rhumatisme·Thiago Costa Pamplona da SilvaSamuel Katsuyuki Shinjo
Jan 16, 2016·Clinical Reviews in Allergy & Immunology·Siamak Moghadam-KiaRohit Aggarwal
Oct 2, 2012·Dermatologic Clinics·Joshua W HagenA Neil Crowson
Jul 12, 2011·Autoimmunity Reviews·Isabelle Marie, Luc Mouthon
Mar 24, 2016·Revista brasileira de reumatologia·Orhan ZenginAhmet Mesut Onat
Sep 17, 2013·Muscle & Nerve·Teerin LiewluckJennifer A Tracy
Jun 30, 2012·Dermatologic Therapy·Christina Lam, Ruth Ann Vleugels
Apr 21, 2012·International Journal of Dermatology·Ahmad Nofal, Eman Salah El-Din
Jun 21, 2011·Annals of Neurology·UNKNOWN Muscle Study Group
Feb 19, 2013·Journal of Cellular and Molecular Medicine·Xiaoren TangSalomon Amar
Feb 18, 2014·Journal of the American Academy of Dermatology·Dane DicaroScott R Dalton
Feb 3, 2012·Immunopharmacology and Immunotoxicology·Giampiero GirolomoniGino Antonio Vena
Feb 22, 2011·La Presse médicale·Isabelle Marie
Jul 17, 2012·Mayo Clinic Proceedings·Olayemi SokumbiKenneth J Warrington
Apr 22, 2016·Journal of Internal Medicine·C V Oddis
Apr 17, 2013·Revista brasileira de reumatologia·Samuel Katsuyuki ShinjoJulio Cesar Bertacini de Moraes
Mar 7, 2014·TheScientificWorldJournal·Alexandra Maria Giovanna BrunassoCesare Massone
Mar 4, 2017·The Journal of Dermatology·Farah Succaria, Jag Bhawan
Jan 22, 2011·Dermatology : International Journal for Clinical and Investigative Dermatology·Nicole Fett, Rosemarie H Liu
Jul 16, 2011·Dermatology : International Journal for Clinical and Investigative Dermatology·Haur Yueh LeeLuca Borradori
Aug 6, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Andrew J SolomonDennis Bourdette
Aug 18, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K E N Clark, D A Isenberg
Nov 22, 2017·The Journal of Dermatological Treatment·Verena Isak, Joseph L Jorizzo
Mar 3, 2011·The Journal of Rheumatology·Takao Nagashima, Seiji Minota
Jul 12, 2017·Expert Review of Clinical Pharmacology·Zoltán GrigerKatalin Dankó
Sep 2, 2019·Current Rheumatology Reports·Kristen L ChenVictoria P Werth
Jan 14, 2018·Journal of Cutaneous Pathology·Lauren LevyChristine J Ko
May 3, 2018·Inflammatory Bowel Diseases·Eirini TheodorakiIoannis E Koutroubakis
Oct 26, 2018·Frontiers in Pediatrics·Charalampia Papadopoulou, Liza J McCann
Feb 26, 2020·American Journal of Clinical Dermatology·Gabriela A CobosRuth Ann Vleugels
Jul 24, 2018·Current Treatment Options in Neurology·Namita A Goyal, Tahseen Mozaffar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Zeitschrift für Haut- und Geschlechtskrankheiten
H GRIMMER
The Journal of Pediatrics
S BITNUMH C HOPPS
Archives belges de dermatologie et de syphiligraphie
E DAUBRESSE, GERAIN
Bulletin de la Société française de dermatologie et de syphiligraphie
R DEGOSJ POULET
The Australasian Journal of Dermatology
N J Callan
© 2021 Meta ULC. All rights reserved