Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model.

Arthritis and Rheumatism
Philana Ling LinJoanne L Flynn

Abstract

An increased risk of tuberculosis has been documented in humans treated with tumor necrosis factor alpha (TNFalpha)-neutralizing agents. In murine models, impaired signaling by TNF causes exacerbation of both acute and chronic infection associated with aberrant granuloma formation and maintenance. This study was undertaken to investigate immune modulation in the setting of TNF neutralization in primary and latent tuberculosis in a non-human primate model. Cynomolgus macaques 4 years of age or older were infected with Mycobacterium tuberculosis and subjected to clinical, microbiologic, immunologic, and radiographic examinations. Monkeys were classified as having active or latent disease 6-8 months after infection, based on clinical criteria. Monkeys used in acute infection studies were randomized to receive either adalimumab (prior to and during infection) or no treatment. Monkeys with latent infection that were randomized to receive TNF-neutralizing agent were given either an inhibitor of soluble TNF, recombinant methionyl human soluble TNF receptor I (p55-TNFRI), or adalimumab. Control monkeys with latent infection were given no treatment or saline. Data from previously studied monkeys with active or latent disease were also u...Continue Reading

Citations

Jul 1, 2011·Immunologic Research·Hannah P Gideon, JoAnne L Flynn
Jul 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Philana Ling LinJoanne L Flynn
Apr 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Frank HeutsMartin E Rottenberg
Jan 20, 2011·Infection and Immunity·Collin R Diedrich, Joanne L Flynn
May 14, 2010·PLoS Computational Biology·Mohammad Fallahi-SichaniJennifer J Linderman
Jan 12, 2013·PloS One·Nidhi KapoorPappachan E Kolattukudy
May 14, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H EsmailR J Wilkinson
May 14, 2014·Seminars in Immunology·Anca Dorhoi, Stefan H E Kaufmann
Nov 13, 2012·Medical Microbiology and Immunology·Satria A PrabowoTjip S van der Werf
Nov 10, 2013·Disease Models & Mechanisms·Venkata Ramanarao ParasaMaria Lerm
May 15, 2010·Science·David G RussellJoAnne L Flynn
Jan 22, 2011·Clinical & Developmental Immunology·Markos AbebeT Mark Doherty
Jul 6, 2016·PLoS Pathogens·Philana Ling LinJoAnne L Flynn
Dec 22, 2012·Microbial Pathogenesis·Jonathan M PittAnne O'Garra
Jul 28, 2016·The Journal of Infectious Diseases·Collin R DiedrichRobert J Wilkinson
Mar 11, 2017·Frontiers in Immunology·Nai-Jen HsuMuazzam Jacobs
Jan 13, 2018·Frontiers in Immunology·Hayley C WarsinskeDenise E Kirschner
Jun 26, 2015·Clinical and Vaccine Immunology : CVI·A D WhiteS A Sharpe
Sep 4, 2014·Microbiology and Molecular Biology Reviews : MMBR·Noton K Dutta, Petros C Karakousis
Dec 31, 2014·Infection and Immunity·Juliet C Peña, Wen-Zhe Ho
Aug 12, 2014·The European Respiratory Journal·Jung-Wan YooTae Sun Shim
Apr 23, 2016·The European Respiratory Journal·Li LiLisa A Maier
Dec 22, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eileen A WongJoAnne L Flynn
Jun 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philana Ling Lin, Joanne L Flynn
Feb 16, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohammad Fallahi-SichaniJennifer J Linderman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
J Christian J RayDenise Kirschner
The Journal of Immunology : Official Journal of the American Association of Immunologists
Mohammad Fallahi-SichaniJennifer J Linderman
The Journal of Immunology : Official Journal of the American Association of Immunologists
Mohammad Fallahi-SichaniDenise Kirschner
© 2021 Meta ULC. All rights reserved