Tumor Necrosis Factor Receptor-Associated Factor Regulation of Nuclear Factor κB and Mitogen-Activated Protein Kinase Pathways

Frontiers in Immunology
Jian-Hong Shi, Shao-Cong Sun

Abstract

Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally related proteins that transduces signals from members of TNFR superfamily and various other immune receptors. Major downstream signaling events mediated by the TRAF molecules include activation of the transcription factor nuclear factor κB (NF-κB) and the mitogen-activated protein kinases (MAPKs). In addition, some TRAF family members, particularly TRAF2 and TRAF3, serve as negative regulators of specific signaling pathways, such as the noncanonical NF-κB and proinflammatory toll-like receptor pathways. Thus, TRAFs possess important and complex signaling functions in the immune system and play an important role in regulating immune and inflammatory responses. This review will focus on the role of TRAF proteins in the regulation of NF-κB and MAPK signaling pathways.

References

Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·H B ShuD V Goeddel
Apr 28, 1997·Biochemical and Biophysical Research Communications·L M BoucherT W Mak
Nov 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·S SanjabiS T Smale
Jun 29, 2001·Nature Immunology·J YangB Su
Jan 5, 2002·The Journal of Biological Chemistry·Pu XiaMathew A Vadas
Feb 28, 2002·Annual Review of Immunology·Chen DongRichard A Flavell
Jul 2, 2003·Molecular and Cellular Biology·S BeinkeS C Ley
Sep 2, 2003·Nature Reviews. Immunology·Bharat B Aggarwal
Oct 28, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Hao Wu, Joseph R Arron
Jun 17, 2004·Molecular and Cellular Biology·Michael WaterfieldShao-Cong Sun
Jun 25, 2004·The Biochemical Journal·Sören Beinke, Steven C Ley
Aug 26, 2004·Molecular Cell·Atsuhiro KanayamaZhijian J Chen
Mar 4, 2005·Molecular and Cellular Biology·You-Sun KimZheng-Gang Liu
Mar 18, 2005·Annual Review of Immunology·Tania H Watts
Sep 17, 2005·Genes & Development·Shomyseh SanjabiStephen T Smale
Sep 28, 2005·Nature Immunology·Shintaro SatoShizuo Akira
Jun 2, 2006·The Journal of Biological Chemistry·Jinzhong QinXiaoxia Li
Oct 4, 2006·The Journal of Experimental Medicine·Jeannie Q HeGenhong Cheng

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Citations

Jan 16, 2020·Environmental Health Perspectives·Pierre-André LafonVéronique Perrier
Feb 7, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kidong KangGang Min Hur
Apr 11, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yang ShenJian-Hong Shi
May 6, 2020·Cells·Baptiste DumétierLaurence Dubrez
Sep 27, 2019·Frontiers in Immunology·Jennifer KreckelHarald Wajant
Apr 30, 2020·International Journal of Molecular Sciences·Laura D'IgnazioSonia Rocha
May 2, 2019·Frontiers in Immunology·Ning SongLinlin Guo
May 15, 2019·International Journal of Molecular Sciences·Delvac OceandyNicholas Stafford
Jan 10, 2019·Cell & Bioscience·Xiaoping XieShao-Cong Sun
Nov 16, 2018·International Journal of Molecular Sciences·Antonio PisanoGiuseppe Fiume
Jun 11, 2019·Frontiers in Pharmacology·Kuei-Yi HungShi-Jye Chu
Nov 4, 2020·RNA Biology·Katharina Walther, Leon N Schulte
Dec 30, 2020·Neoplasia : an International Journal for Oncology Research·Ke GongAmyn A Habib
Jan 14, 2021·Signal Transduction and Targeted Therapy·Xiaofei Zhou, Shao-Cong Sun
Dec 6, 2020·The Journal of Biological Chemistry·Alexandra M WhiteleyDaniel Finley
Dec 19, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Shun-Guang WeiRobert B Felder
Nov 4, 2020·Journal of Physiology and Biochemistry·Ghaidafeh Akbari
Feb 16, 2021·Frontiers in Cell and Developmental Biology·Edward Beamer, Sonia A L Corrêa
Feb 25, 2021·The FEBS Journal·Pratikshya Pandey, Gunasegaran Karupiah
Mar 19, 2021·Frontiers in Cellular and Infection Microbiology·Luis Johnson KangaleEric Ghigo
Mar 30, 2021·Journal of the American Chemical Society·Ayesha M Patel, E Neil G Marsh
Apr 3, 2021·Scientific Reports·Orlando LaitanoThomas L Clanton
Mar 30, 2021·Journal of Alzheimer's Disease : JAD·Robert MorrisFeng Cheng
Apr 17, 2021·Scientific Reports·Fatema Al-RashedRasheed Ahmad
May 22, 2021·Frontiers in Immunology·Ricarda Cortés-VieyraVíctor M Baizabal-Aguirre

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Methods Mentioned

BETA
ubiquitination
nuclear translocation
deubiquitination

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