Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) improves the innate immune response and enhances survival in murine polymicrobial sepsis

Critical Care Medicine
Katharina CziupkaClaus-Dieter Heidecke

Abstract

To investigate the role of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) in postoperative polymicrobial abdominal sepsis.Sepsis is the leading cause of death among critically ill surgical patients. TRAIL is commonly known as an apoptosis-inducing agent in cancer cells. It also plays an important role in the regulation of inflammatory reactions. The role of TRAIL in polymicrobial sepsis is still unclear. Experimental animal model. University laboratory. C57BL/6 mice. Colon ascendens stent peritonitis (CASP) was induced in female mice. One hour, 24 hrs, and 48 hrs after induction of CASP, murine recombinant TRAIL was given intravenously. This study demonstrates a protective effect of TRAIL in CASP, an experimental model of murine polymicrobial sepsis. Intravenous administration of recombinant TRAIL to mice after CASP induction led to highly significantly prolonged survival. The migration of effector cells into the peritoneal cavity was strongly enhanced. Consequently, TRAIL-treated mice eliminated bacteria significantly better from the peritoneal cavity, the source of infection. Systemic spread of gut bacteria was also reduced by several orders of magnitude. As a result of the reduced systemic spread of ba...Continue Reading

References

Mar 23, 2001·Nature Immunology·R S HotchkissI E Karl
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B HilliardY Chen
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julian J LumAndrew D Badley
Jul 5, 2006·The Journal of Experimental Medicine·Shixin QinHuan Yang
Nov 14, 2006·The International Journal of Biochemistry & Cell Biology·Erika CretneyMark J Smyth
Feb 27, 2007·Intensive Care Medicine·Christoph EngelKonrad Reinhart
Jun 16, 2007·The Journal of Clinical Investigation·Olaf HoffmannJoerg R Weber
Dec 15, 2007·The Journal of Clinical Investigation·Niklas FinnbergWafik S El-Deiry
Jan 2, 2009·Cancer Treatment Reviews·Devalingam MahalingamAfshin Samali

❮ Previous
Next ❯

Citations

Dec 15, 2015·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·K BeyerC-D Heidecke
Jun 25, 2013·The Journal of Pathology·James N FullertonDerek W Gilroy
Mar 14, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Piya ChaemsaithongTinnakorn Chaiworapongsa
May 22, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Piya ChaemsaithongSonia S Hassan
Jan 1, 2012·Drug Discovery Today. Disease Models·Scott B HuJane C Deng
Jan 15, 2015·Molecular Oncology·Zhenyu YaoDexian Zheng
Jun 3, 2017·Infectious Agents and Cancer·Katharina BeyerWolfram von Bernstorff
Oct 3, 2019·Cancers·Duygu SagGerhard Wingender
Aug 10, 2020·Shock·Yibing WeiDaniel Remick
Apr 4, 2021·Journal of Clinical Medicine·Katarzyna KakarekoTomasz Hryszko
Sep 25, 2021·Journal of Leukocyte Biology·Xinru QiuMeera G Nair

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis