Tumor necrosis factors alpha and beta can stimulate bone resorption in cultured mouse calvariae by a prostaglandin-independent mechanism

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
U H Lerner, A Ohlin

Abstract

Human recombinant tumor necrosis factors alpha and beta (TNF-alpha and TNF-beta), at and above 1 ng/ml (approximately equal to 70 pM), caused a dose- and time-dependent enhancement of 45Ca release from neonatal mouse calvarial bones in vitro. In addition, TNF-alpha and TNF-beta (3-100 ng/ml) caused a dose-dependent stimulation of prostaglandin E2 (PGE2) formation in the calvarial bones. TNF-alpha also enhanced the biosynthesis of PGI2, as assessed by analysis of the stable breakdown product 6-keto-PGF1 alpha. The stimulatory actions of TNF-alpha and TNF-beta on PGE2 formation was maximal at 12 h. Indomethacin, flurbiprofen, and meclofenamic acid, three structurally unrelated nonsteroidal antiinflammatory drugs, abolished PGE2 biosynthesis induced by TNF-alpha and TNF-beta (100 ng/ml). The 45Ca release stimulated by TNF-alpha and TNF-beta (100 ng/ml), however, was only slightly reduced by indomethacin, flurbiprofen, and meclofenamic acid. The partial inhibitory effect of indomethacin on 45Ca release was seen over a wide range of TNF-alpha concentrations, without affecting the concentration producing half-maximal stimulatory response. TNF-alpha and TNF-beta (100 ng/ml) stimulated bone matrix breakdown, as assessed by analysis of ...Continue Reading

References

May 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·O LjunggrenU H Lerner
Feb 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F Russo-Marie
Jun 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·O LjunggrenU H Lerner
Mar 1, 1989·Acta Endocrinologica·O Ljunggren, U H Lerner
Jul 14, 1989·Biochemical and Biophysical Research Communications·D N Tatakis, R Dziak
Oct 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M GowenG R Mundy
Oct 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·U H Lerner
Jan 14, 1986·Biochemical and Biophysical Research Communications·Y Shiina-IshimiT Suda
Aug 27, 1987·The New England Journal of Medicine·I R GarrettG R Mundy
Feb 12, 1987·The New England Journal of Medicine·B Beutler, A Cerami
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·F HirataJ Axelrod

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Citations

Jan 1, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A SabokbarN A Athanasou
Dec 8, 2010·Critical Reviews in Eukaryotic Gene Expression·Narayanan Parameswaran, Sonika Patial
Sep 6, 2013·Immunological Investigations·Pedro P C Souza, Ulf H Lerner
Mar 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y SakumaK Nakao
Nov 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·U H Lerner
Jul 21, 2011·Journal of Bone and Mineral Metabolism·Shaohui ZongGaofeng Zeng
Nov 15, 2011·Journal of Leukocyte Biology·M Victoria DelpinoGuillermo H Giambartolomei
May 16, 1998·Journal of Clinical Periodontology·L BoströmJ Bergström
Feb 15, 2000·The Journal of Biological Chemistry·Y AzumaA Kudo
Jan 23, 2002·Gene Therapy·A W BaltzerC H Evans
Sep 1, 1995·Journal of Cellular Biochemistry·S L TeitelbaumF P Ross
Jun 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R B KimbleR Pacifici
Sep 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J B RosenquistU H Lerner
Sep 1, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S MoronyC R Dunstan
Mar 8, 2017·Frontiers in Microbiology·Guillermo H GiambartolomeiM Victoria Delpino
Dec 1, 1995·Oral Diseases·G L Howells
Mar 2, 2017·International Journal of Molecular Sciences·Hyun-Jung ParkHyung-Ryong Kim
Sep 1, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R L Van bezooijenC W Löwik
Apr 1, 1995·Journal of Biomedical Materials Research·S M Horowitz, M A Purdon

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