Tumor Penetrating Theranostic Nanoparticles for Enhancement of Targeted and Image-guided Drug Delivery into Peritoneal Tumors following Intraperitoneal Delivery

Theranostics
Ning GaoLily Yang

Abstract

The major obstacles in intraperitoneal (i.p.) chemotherapy of peritoneal tumors are fast absorption of drugs into the blood circulation, local and systemic toxicities, inadequate drug penetration into large tumors, and drug resistance. Targeted theranostic nanoparticles offer an opportunity to enhance the efficacy of i.p. therapy by increasing intratumoral drug delivery to overcome resistance, mediating image-guided drug delivery, and reducing systemic toxicity. Herein we report that i.p. delivery of urokinase plasminogen activator receptor (uPAR) targeted magnetic iron oxide nanoparticles (IONPs) led to intratumoral accumulation of 17% of total injected nanoparticles in an orthotopic mouse pancreatic cancer model, which was three-fold higher compared with intravenous delivery. Targeted delivery of near infrared dye labeled IONPs into orthotopic tumors could be detected by non-invasive optical and magnetic resonance imaging. Histological analysis revealed that a high level of uPAR targeted, PEGylated IONPs efficiently penetrated into both the peripheral and central tumor areas in the primary tumor as well as peritoneal metastatic tumor. Improved theranostic IONP delivery into the tumor center was not mediated by nonspecific mac...Continue Reading

Citations

Apr 7, 2020·Current Pharmaceutical Design·James T OswaldShirley Tang
Jul 28, 2018·Scientific Reports·Maria V EfremovaUlf Wiedwald
Nov 21, 2019·Nanomaterials·Marina S DukhinovaVladimir V Vinogradov
Aug 9, 2020·International Journal of Nanomedicine·Barbara BortotStefania Biffi
Oct 27, 2018·Journal of Imaging·Dong-Hyun Kim
Mar 13, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Nicholas E Wojtynek, Aaron M Mohs
Jun 27, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Madeline T OlsonAaron M Mohs
Aug 18, 2018·Frontiers in Pharmacology·David ChangMaria Kavallaris
Mar 29, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yu HangDavid Oupický
May 22, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Zhengze LuQin He

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Methods Mentioned

BETA
xenograft
transmission electron microscopy

Software Mentioned

Image J

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