PMID: 2494119Mar 15, 1989Paper

Tumor prevention by a xanthate compound in experimental mouse-skin tumorigenesis

International Journal of Cancer. Journal International Du Cancer
G FürstenbergerG Sauer

Abstract

The antiviral and antitumoral compound tricyclodecan-9-yl-xanthogenate (D609), which is an inhibitor of protein kinase C activation, has been used for tumor prevention in vivo. When applied chronically together with 12-O-tetradecanoylphorbol-13-acetate (TPA) in the classic initiation-promotion mouse-skin model, D609 prevented tumor induction in a dose-dependent manner. At the concentration that inhibited tumor formation by 97%, no toxic effects were detected and the TPA-induced hyperplasia remained unaffected. As D609 failed to prevent the activity of a chronically applied carcinogen, it is concluded that the observed tumor prevention achieved with D609 is tumor-promotion-specific and is not due to killing of tumor cells.

References

Aug 1, 1988·Experimental Cell Research·K Müller-DeckerG Sauer
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R J Davis, M P Czech
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G SauerA Scherm
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G FürstenbergerF Marks

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