Tumor Primary Location May Affect Metastasis Pattern for Patients with Stage IV NSCLC: A Population-Based Study

Journal of Oncology
Qinge ShanZhehai Wang

Abstract

Most patients with nonsmall cell lung cancer (NSCLC) were initially diagnosed with distant metastasis. At present, there is no study to clarify the correlation between the primary location of the tumor and the metastasis pattern in advanced NSCLC. So we conducted this study to explored the relationship between the tumor primary location and metastasis pattern in stage IV NSCLC. A total of 19,295 eligible patients were identified from 2010 to 2012 in the SEER database. The main endpoint of our study was overall survival (OS). The survival curves were created by using the Kaplan-Meier method and compared by the usage of the Log Rank test. The clinical variable characteristics were compared by the chi-square test, and multivariate logistic regression analyses were used to evaluate the risk factors on metastasis patterns. All statistical P values were two-sided, and it was considered statistically significant when P ≤ 0.05. We found that different proportions of metastatic sites could be found in different tumor primary locations. In addition, the prognosis of lung metastasis was relatively good in patients with tumor location in main bronchus (P < 0.001), upper lobe (P < 0.001), lower lobe (P < 0.001) , and middle lobe (P = 0.005)...Continue Reading

References

Jun 7, 2000·Lancet·P C HoffmanE E Vokes
Apr 16, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Christophoros S KotoulasAchilles Lioulias
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward
Dec 14, 2011·Interactive Cardiovascular and Thoracic Surgery·Daigo KawanoYu Nakaji
Aug 16, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Bing-Yen WangYung-Po Liaw
Jun 4, 2014·CA: a Cancer Journal for Clinicians·Carol E DeSantisAhmedin Jemal
Aug 19, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M RiihimäkiK Hemminki
Dec 4, 2014·Molecular and Clinical Oncology·Tomohiro TamuraNobuyuki Hizawa
Mar 10, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kuan-Li WuMing-Shyan Huang
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Aug 31, 2016·Lancet·Fred R HirschLuis Paz-Ares
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Feb 12, 2017·Cell·Nicholas McGranahan, Charles Swanton
Oct 13, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leora HornWilfried E E Eberhardt
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 25, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Antonin LevyUNKNOWN Young Investigators EORTC Lung Cancer Group (YI EORTC LCG)
May 12, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Lin YangYang Xie
Oct 23, 2018·Therapeutic Advances in Medical Oncology·Nerea Muñoz-UncetaLuis Paz-Ares
Nov 13, 2019·Journal of Gastrointestinal Cancer·Apostolos GaitanidisMichail Pitiakoudis
Nov 19, 2019·Medicinski Glasnik : Official Publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina·Kemal Grbić, Bakir Mehić
Nov 19, 2019·Journal of Thoracic Disease·Dashan AiKuaile Zhao
Feb 18, 2020·Critical Reviews in Oncology/hematology·Bao-Dong QinYuan-Sheng Zang

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

Statistical Product and Service Solutions
∗ Stat
SEER

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.