Tumor progression: chance and necessity in Darwinian and Lamarckian somatic (mutationless) evolution

Progress in Biophysics and Molecular Biology
Sui Huang

Abstract

Current investigation of cancer progression towards increasing malignancy focuses on the molecular pathways that produce the various cancerous traits of cells. Their acquisition is explained by the somatic mutation theory: tumor progression is the result of a neo-Darwinian evolution in the tissue. Herein cells are the units of selection. Random genetic mutations permanently affecting these pathways create malignant cell phenotypes that are selected for in the disturbed tissue. However, could it be that the capacity of the genome and its gene regulatory network to generate the vast diversity of cell types during development, i.e., to produce inheritable phenotypic changes without mutations, is harnessed by tumorigenesis to propel a directional change towards malignancy? Here we take an encompassing perspective, transcending the orthodoxy of molecular carcinogenesis and review mechanisms of somatic evolution beyond the Neo-Darwinian scheme. We discuss the central concept of "cancer attractors" - the hidden stable states of gene regulatory networks normally not occupied by cells. Noise-induced transitions into such attractors provide a source for randomness (chance) and regulatory constraints (necessity) in the acquisition of nove...Continue Reading

References

Sep 21, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S J Gould, R C Lewontin
Oct 1, 1976·Science·P C Nowell
Dec 13, 1991·Science·H FrauenfelderP G Wolynes
Jun 1, 1971·Journal of Theoretical Biology·S Kauffman
Oct 1, 1995·Trends in Genetics : TIG·D N Louis, J F Gusella
Apr 1, 1993·Trends in Genetics : TIG·B Vogelstein, K W Kinzler
Feb 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·F MüllerH Tobler
Dec 6, 1996·Science·C J Sherr
Apr 1, 1972·Journal of the History of Biology·E Mayr
Nov 1, 2001·Differentiation; Research in Biological Diversity·M Kloc, B Zagrodzinska
Jan 22, 2002·Physical Review Letters·E Aurell, K Sneppen
Aug 23, 2002·Nature·René Bernards, Robert A Weinberg
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Manfred Eigen
Jan 1, 1961·Cold Spring Harbor Symposia on Quantitative Biology·J MONOD, F JACOB
Jan 28, 2004·Cell·Sepideh Khorasanizadeh
Sep 15, 2004·Journal of Theoretical Biology·Stuart Kauffman
Sep 24, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ana M Soto, Carlos Sonnenschein
Nov 2, 2004·Nature Reviews. Cancer·Robert A Gatenby, Robert J Gillies
Dec 29, 2004·Cell·Stefan Kubicek, Thomas Jenuwein
Jan 27, 2005·Environmental and Molecular Mutagenesis·Jason H Bielas, Lawrence A Loeb
Apr 2, 2005·Nature Reviews. Cancer·Michael DeanSusan Bates
May 11, 2005·Nature Reviews. Genetics·Mads KaernJames J Collins
May 21, 2005·Physical Review Letters·Sui HuangDonald E Ingber
Jun 23, 2005·Cancer Biology & Therapy·Mikhail V Blagosklonny
Jul 20, 2005·Journal of Clinical Pharmacology·Vera S Donnenberg, Albert D Donnenberg
Aug 16, 2005·Current Opinion in Genetics & Development·François Fuks
Dec 22, 2005·Nature Reviews. Genetics·Alfonso Martinez Arias, Penelope Hayward
Jan 18, 2006·Annual Review of Medicine·Judah Folkman
Feb 21, 2006·Cancer Research·Max S WichaGabriela Dontu
Mar 15, 2006·Nature Reviews. Genetics·Eric J Richards
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M I Freidlin
Apr 15, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Harry Rubin
Apr 25, 2006·Cell·Patrick Trojer, Danny Reinberg
Jul 22, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anthony D YangLee M Ellis
Nov 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jason H BielasLawrence A Loeb
Dec 26, 2006·Journal of Theoretical Biology·Maximino AldanaOsbaldo Resendiz
Feb 27, 2007·Cell·Tony Kouzarides
Feb 28, 2007·Studies in History and Philosophy of Biological and Biomedical Sciences·Angela N H Creager
Apr 5, 2007·Current Biology : CB·Mark Ptashne
Jun 15, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Bruce GottliebMark Trifiro

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Citations

Sep 26, 2013·Molecular Cancer·Prakash KulkarniRahul V Kulkarni
Jul 5, 2013·Chaos·C KadelkaR Laubenbacher
Apr 17, 2014·Journal of Biosciences·Carlos SonnenscheinPrakash Kulkarni
Oct 16, 2015·Molecular Biology and Evolution·Han Chen, Xionglei He
Apr 12, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ricard V SoléJosep Sardanyés
Jul 17, 2015·Cancer Medicine·Bingya LiuDezhong Joshua Liao
Apr 23, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Kailash Narayan, Ming Yin Lin
Oct 24, 2013·Systems Biology in Reproductive Medicine·Batoul Y AbdallahHenry H Q Heng
Aug 13, 2013·Studies in History and Philosophy of Biological and Biomedical Sciences·Jan Baedke
Nov 5, 2014·Frontiers in Oncology·Sui Huang
Sep 21, 2013·Nature Communications·Angela Oliveira PiscoSui Huang
Dec 22, 2012·Expert Review of Proteomics·Lianhong LiGary Guishan Xiao
Dec 14, 2019·British Journal of Cancer·Charles C Bell, Omer Gilan
Aug 21, 2020·Evolution; International Journal of Organic Evolution·Charles RocabertSamuel Bernard
Dec 13, 2017·Proceedings of the National Academy of Sciences of the United States of America·Yapeng SuJames R Heath
Feb 25, 2020·Cancer Convergence·Yang ShenWolfgang Losert
Nov 23, 2017·Cancer Research·Amy Brock, Sui Huang
Jul 19, 2018·Cell·Florian RambowJean-Christophe Marine
Apr 20, 2021·Cancer Metastasis Reviews·Hendrik Hld VandyckVéronique Winnepenninckx
May 25, 2021·Blood Cancer Discovery·Emily Schwenger, Ulrich Steidl
May 26, 2021·Cell Stress & Chaperones·Armando Aranda-Anzaldo, Myrna A R Dent
Jul 8, 2021·Cancer Discovery·Emily Schwenger, Ulrich Steidl

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