PMID: 8943058Nov 26, 1996Paper

Tumor progression to the metastatic state involves structural modifications in DNA markedly different from those associated with primary tumor formation

Proceedings of the National Academy of Sciences of the United States of America
Donald C MalinsS J Gunselman

Abstract

Wavenumber-absorbance relationships of infrared spectra of DNA analyzed by principal components analysis may be expressed as points in space. Each point represents a highly discriminating measure of DNA structure. Structural modifications of DNA, such as those induced by free radicals, alter vibrational and rotational motion and consequently change the spatial location of the points. Using this technology to analyze breast tumor DNA, we revealed a 94 degrees difference in direction between the progression of normal DNA-->primary tumor DNA and the progression of primary tumor DNA-->metastatic tumor DNA (P < 0.001). This sharp directional change was accompanied by a substantial increase in the structural diversity of the metastatic tumor DNA (P = 0.003), which, on the basis of the volume of the core cluster of points, could comprise as many as 11 x 10(9) different phenotypes. This suggests that the heterogeneity and varied physiological properties known to characterize malignant tumor cell populations may at least partially arise from these diverse phenotypes. The evidence suggests that the progression to the metastatic state involves structural modifications in DNA that are markedly different from the modifications associated wi...Continue Reading

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Citations

Aug 1, 1997·Nature Medicine·D C MalinsS J Gunselman
Apr 30, 2011·Nature Methods·Francis L Martin
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·D C MalinsS J Gunselman
Mar 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Donald C MalinsJerry L Spivak
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·D C MalinsM Vinson
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Donald C MalinsKarl Erik Hellström
Nov 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·D C MalinsM A Vinson
Jul 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Donald C MalinsKatie M Anderson
Jun 9, 1998·Annals of the New York Academy of Sciences·D L DavisE Sittner
Oct 3, 2009·Applied Spectroscopy·M P MannS Mordechai
Jul 9, 1999·Environmental and Molecular Mutagenesis·W J MeehanG K Ostrander
Apr 25, 2009·Molecular and Cellular Biochemistry·Alessia Galasso, Massimo Zollo

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