Tumor pseudoprogression and true progression following gamma knife radiosurgery for recurrent ependymoma

Journal of the Chinese Medical Association : JCMA
Chih-Chun WuHsiu-Mei Wu

Abstract

Gamma knife radiosurgery (GKRS) has become an effective salvage therapeutic option for recurrent ependymomas. However, its effectiveness can be assessed only by neuroimaging before clinical deterioration occurs. We analyzed the evolution of post-GKRS magnetic resonance imaging (MRI) features and sought to establish the feasibility of timely appropriate clinical management of the recurrent tumors. We retrospectively investigated 19 recurrent ependymomas of 11 patients treated with GKRS in our hospital from 1994 to 2013. All included tumors had sequential MRI at 3-6-month intervals, and tumor response was volumetrically calculated on consecutive MRI. Post-GKRS tumors might show an increased enhancement or loss of enhancement associated with tumor enlargement or straight shrinkage. Seven of 19 tumors (37%) had continuously regressed or remained stable up to the last follow-up. Twelve of 19 tumors (63%) showed enlargement of enhancing lesions through examination of the post-GKRS follow-up MRI within the first 18 months. Five of 12 tumors (42%) showed continuous enlargement, which was interpreted as true progression; seven of 12 (58%) exhibited transient increasing enhanced volume that resolved within 6 months, and which was interpr...Continue Reading

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